Association of depression with mortality in an elderly treated hypertensive population
Background:Both elevated blood pressure and/or depression increase the risk of cardiovascular disease and mortality. This study in treated elderly hypertensive patients explored the incidence of depression, its association (pre-existing and incident) with mortality and predictors of incident depress...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Cambridge University Press
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/74402 |
| _version_ | 1848763264542965760 |
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| author | Chowdhury, E. Berk, M. Nelson, M. Wing, L. Reid, Christopher |
| author_facet | Chowdhury, E. Berk, M. Nelson, M. Wing, L. Reid, Christopher |
| author_sort | Chowdhury, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background:Both elevated blood pressure and/or depression increase the risk of cardiovascular disease and mortality. This study in treated elderly hypertensive patients explored the incidence of depression, its association (pre-existing and incident) with mortality and predictors of incident depression.Methods:Data from 6,083 hypertensive patients aged =65 years enrolled in the Second Australian National Blood Pressure study were used. Participants were followed for a median of 10.8 years (including 4.1 years in-trial) and classified into: "no depression," "pre-existing" and "incident" depression groups based on either being "diagnosed with depressive disorders" and/or "treated with an anti-depressant drug" at baseline or during in-trial period. Further, we redefined "depression" restricted to presence of both conditions for sensitivity analyses. For the current study, end-points were all-cause and any cardiovascular mortality.Results:313 (5%) participants had pre-existing depression and a further 916 (15%) participants developed depression during the trial period (incidence 4% per annum). Increased (hazard-ratio, 95% confidence-interval) all-cause mortality was observed among those with either pre-existing (1.23, 1.01-1.50; p = 0.03) or incident (1.26, 1.12-1.41; p < 0.001) depression compared to those without. For cardiovascular mortality, a 24% increased risk (1.24, 1.05-1.47; p = 0.01) was observed among those with incident depression. The sensitivity analyses, using the restricted depression definition showed similar associations. Incident depression was associated with being female, aged =75 years, being an active smoker at study entry, and developing new diabetes during the study period.Conclusions:This elderly cohort had a high incidence of depression irrespective of their randomised antihypertensive regimen. Both pre-existing and incident depression were associated with increased mortality. |
| first_indexed | 2025-11-14T11:00:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-74402 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:00:42Z |
| publishDate | 2018 |
| publisher | Cambridge University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-744022019-07-16T03:17:17Z Association of depression with mortality in an elderly treated hypertensive population Chowdhury, E. Berk, M. Nelson, M. Wing, L. Reid, Christopher Background:Both elevated blood pressure and/or depression increase the risk of cardiovascular disease and mortality. This study in treated elderly hypertensive patients explored the incidence of depression, its association (pre-existing and incident) with mortality and predictors of incident depression.Methods:Data from 6,083 hypertensive patients aged =65 years enrolled in the Second Australian National Blood Pressure study were used. Participants were followed for a median of 10.8 years (including 4.1 years in-trial) and classified into: "no depression," "pre-existing" and "incident" depression groups based on either being "diagnosed with depressive disorders" and/or "treated with an anti-depressant drug" at baseline or during in-trial period. Further, we redefined "depression" restricted to presence of both conditions for sensitivity analyses. For the current study, end-points were all-cause and any cardiovascular mortality.Results:313 (5%) participants had pre-existing depression and a further 916 (15%) participants developed depression during the trial period (incidence 4% per annum). Increased (hazard-ratio, 95% confidence-interval) all-cause mortality was observed among those with either pre-existing (1.23, 1.01-1.50; p = 0.03) or incident (1.26, 1.12-1.41; p < 0.001) depression compared to those without. For cardiovascular mortality, a 24% increased risk (1.24, 1.05-1.47; p = 0.01) was observed among those with incident depression. The sensitivity analyses, using the restricted depression definition showed similar associations. Incident depression was associated with being female, aged =75 years, being an active smoker at study entry, and developing new diabetes during the study period.Conclusions:This elderly cohort had a high incidence of depression irrespective of their randomised antihypertensive regimen. Both pre-existing and incident depression were associated with increased mortality. 2018 Journal Article http://hdl.handle.net/20.500.11937/74402 10.1017/S1041610218000856 Cambridge University Press restricted |
| spellingShingle | Chowdhury, E. Berk, M. Nelson, M. Wing, L. Reid, Christopher Association of depression with mortality in an elderly treated hypertensive population |
| title | Association of depression with mortality in an elderly treated hypertensive population |
| title_full | Association of depression with mortality in an elderly treated hypertensive population |
| title_fullStr | Association of depression with mortality in an elderly treated hypertensive population |
| title_full_unstemmed | Association of depression with mortality in an elderly treated hypertensive population |
| title_short | Association of depression with mortality in an elderly treated hypertensive population |
| title_sort | association of depression with mortality in an elderly treated hypertensive population |
| url | http://hdl.handle.net/20.500.11937/74402 |