Evaluation of the stability of exenatide in aqueous solutions
Exenatide is an Incretin Mimetic which stimulates insulin secretion, suppresses glucagon secretion and inhibits gastric emptying. This study aimed to evaluate the stability of exenatide in aqueous solutions. Exenatide was most stable at pH 6 and the reaction rate was highly temperature dependent. Ex...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/744 |
| _version_ | 1848743467907284992 |
|---|---|
| author | Al Assadi, Ali |
| author_facet | Al Assadi, Ali |
| author_sort | Al Assadi, Ali |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Exenatide is an Incretin Mimetic which stimulates insulin secretion, suppresses glucagon secretion and inhibits gastric emptying. This study aimed to evaluate the stability of exenatide in aqueous solutions. Exenatide was most stable at pH 6 and the reaction rate was highly temperature dependent. Exenatide degradation followed first order kinetics under all conditions employed. Future studies should aim at investigating a more stable exenatide formulation and a more convenient route of administration. |
| first_indexed | 2025-11-14T05:46:02Z |
| format | Thesis |
| id | curtin-20.500.11937-744 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:46:02Z |
| publishDate | 2015 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-7442018-09-17T01:59:39Z Evaluation of the stability of exenatide in aqueous solutions Al Assadi, Ali Exenatide is an Incretin Mimetic which stimulates insulin secretion, suppresses glucagon secretion and inhibits gastric emptying. This study aimed to evaluate the stability of exenatide in aqueous solutions. Exenatide was most stable at pH 6 and the reaction rate was highly temperature dependent. Exenatide degradation followed first order kinetics under all conditions employed. Future studies should aim at investigating a more stable exenatide formulation and a more convenient route of administration. 2015 Thesis http://hdl.handle.net/20.500.11937/744 en Curtin University fulltext |
| spellingShingle | Al Assadi, Ali Evaluation of the stability of exenatide in aqueous solutions |
| title | Evaluation of the stability of exenatide in aqueous solutions |
| title_full | Evaluation of the stability of exenatide in aqueous solutions |
| title_fullStr | Evaluation of the stability of exenatide in aqueous solutions |
| title_full_unstemmed | Evaluation of the stability of exenatide in aqueous solutions |
| title_short | Evaluation of the stability of exenatide in aqueous solutions |
| title_sort | evaluation of the stability of exenatide in aqueous solutions |
| url | http://hdl.handle.net/20.500.11937/744 |