Day or overnight transfusion in critically ill patients: does it matter?

Background and objectives: The timing of blood administration in critically ill patients is first driven by patients' needs. This study aimed to define the epidemiology and significance of overnight transfusion in critically ill patients. Materials and methods: This is a post hoc analysis of a...

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Main Authors:	Aubron, C., Kandane-Rathnayake, R., Andrianopoulos, N., Westbrook, A., Engelbrecht, S., Ozolins, I., Bailey, M., Murray, L., Cooper, D., Wood, E., McQuilten, Z., Pettilä, V., Nichol, A., Syres, G., Phillips, L., Street, A., French, C., Orford, N., Santamaria, J., Bellomo, R., Vallance, S., McArthur, C., McGuiness, S., Newby, L., Simmonds, C., Parke, R., Buhr, H., Goldsmith, D., O'Sullivan, K., Mercer, I., Gazzard, R., Tauschke, C., Hill, D., Fletcher, J., Boschert, C., Koch, G., Ernest, D., Eliott, S., Howe, B., Hawker, F., Ellem, K., Duff, K., Henderson, S., Mehrtens, J., Milliss, D., Wong, H., Arora, S., O'Bree, B., Shepherd, K., Ihle, B., Ho, S., Graan, M., Bernsten, A., Ryan, E., Botha, J., Vuat, J., Kinmonth, A., Fraser, M., Richards, B., Tallott, M., Whitbread, R., Freebairn, R., Thomas, L., Parr, M., Micallef, S., Deshpande, K., Wood, J., Williams, Teresa, Tai, J., Boase, A., Galt, P., King, B., Price, R., Tomlinson, J., Cole, L., Seppelt, I., Weisbrodt, L., Gresham, R., Nikas, M., Laing, J., Bell, J., McHugh, G., Hancock, D., Kirkham, S., Shehabi, Y., Campbell, M.
Format:	Journal Article
Published:	2018
Online Access:	http://hdl.handle.net/20.500.11937/74033

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author	Aubron, C. Kandane-Rathnayake, R. Andrianopoulos, N. Westbrook, A. Engelbrecht, S. Ozolins, I. Bailey, M. Murray, L. Cooper, D. Wood, E. McQuilten, Z. Westbrook, A. Pettilä, V. Nichol, A. Bailey, M. Wood, E. Syres, G. Phillips, L. Street, A. French, C. Murray, L. Orford, N. Santamaria, J. Bellomo, R. Nichol, A. Street, A. Vallance, S. McArthur, C. McGuiness, S. Newby, L. Simmonds, C. Parke, R. Buhr, H. Bellomo, R. Goldsmith, D. O'Sullivan, K. Mercer, I. Gazzard, R. Tauschke, C. Hill, D. Fletcher, J. Boschert, C. Koch, G. Ernest, D. Eliott, S. Howe, B. Hawker, F. Ellem, K. Duff, K. Henderson, S. Mehrtens, J. Milliss, D. Wong, H. Arora, S. O'Bree, B. Shepherd, K. Ihle, B. Ho, S. Ihle, B. Graan, M. Bernsten, A. Ryan, E. Botha, J. Vuat, J. Orford, N. Kinmonth, A. Fraser, M. Richards, B. Tallott, M. Whitbread, R. Freebairn, R. Thomas, L. Parr, M. Micallef, S. Deshpande, K. Wood, J. Williams, Teresa Tai, J. Boase, A. Arora, S. Galt, P. King, B. Price, R. Tomlinson, J. Cole, L. Seppelt, I. Weisbrodt, L. Gresham, R. Nikas, M. Laing, J. Bell, J. McHugh, G. Hancock, D. Kirkham, S. Shehabi, Y. Campbell, M.
author_facet	Aubron, C. Kandane-Rathnayake, R. Andrianopoulos, N. Westbrook, A. Engelbrecht, S. Ozolins, I. Bailey, M. Murray, L. Cooper, D. Wood, E. McQuilten, Z. Westbrook, A. Pettilä, V. Nichol, A. Bailey, M. Wood, E. Syres, G. Phillips, L. Street, A. French, C. Murray, L. Orford, N. Santamaria, J. Bellomo, R. Nichol, A. Street, A. Vallance, S. McArthur, C. McGuiness, S. Newby, L. Simmonds, C. Parke, R. Buhr, H. Bellomo, R. Goldsmith, D. O'Sullivan, K. Mercer, I. Gazzard, R. Tauschke, C. Hill, D. Fletcher, J. Boschert, C. Koch, G. Ernest, D. Eliott, S. Howe, B. Hawker, F. Ellem, K. Duff, K. Henderson, S. Mehrtens, J. Milliss, D. Wong, H. Arora, S. O'Bree, B. Shepherd, K. Ihle, B. Ho, S. Ihle, B. Graan, M. Bernsten, A. Ryan, E. Botha, J. Vuat, J. Orford, N. Kinmonth, A. Fraser, M. Richards, B. Tallott, M. Whitbread, R. Freebairn, R. Thomas, L. Parr, M. Micallef, S. Deshpande, K. Wood, J. Williams, Teresa Tai, J. Boase, A. Arora, S. Galt, P. King, B. Price, R. Tomlinson, J. Cole, L. Seppelt, I. Weisbrodt, L. Gresham, R. Nikas, M. Laing, J. Bell, J. McHugh, G. Hancock, D. Kirkham, S. Shehabi, Y. Campbell, M.
author_sort	Aubron, C.
building	Curtin Institutional Repository
collection	Online Access
description	Background and objectives: The timing of blood administration in critically ill patients is first driven by patients' needs. This study aimed to define the epidemiology and significance of overnight transfusion in critically ill patients. Materials and methods: This is a post hoc analysis of a prospective multicentre observational study including 874 critically ill patients receiving red blood cells, platelets, fresh frozen plasma (FFP) or cryoprecipitate. Characteristics of patients receiving blood only during the day (8 am up until 8 pm) were compared to those receiving blood only overnight (8 pm up until 8 am). Characteristics of transfusion were compared, and factors independently associated with major bleeding were analysed. Results: The 287 patients transfused during the day only had similar severity and mortality to the 258 receiving blood products overnight only. Although bleeding-related admission diagnoses were similar, major bleeding was the indication for transfusion in 12% of patients transfused in daytime only versus 30% of patients transfused at night only (P < 0·001). Similar total amount of blood products were transfused at day and night (2856 versus 2927); however, patients were more likely to receive FFP and cryoprecipitate at night compared with daytime. Overnight transfusion was independently associated with increased odds of major bleeding (odds ratio, 3·16, 95% confidence interval, 2·00–5·01). Conclusion: Transfusion occurs evenly across day and night in ICU; nonetheless, there are differences in type of blood products administered that reflect differences in indication. Critically ill patients were more likely to receive blood for major bleeding at night irrespective of admission diagnosis.
first_indexed	2025-11-14T10:59:04Z
format	Journal Article
id	curtin-20.500.11937-74033
institution	Curtin University Malaysia
institution_category	Local University
last_indexed	2025-11-14T10:59:04Z
publishDate	2018
recordtype	eprints
repository_type	Digital Repository
spelling	curtin-20.500.11937-740332019-07-17T03:37:07Z Day or overnight transfusion in critically ill patients: does it matter? Aubron, C. Kandane-Rathnayake, R. Andrianopoulos, N. Westbrook, A. Engelbrecht, S. Ozolins, I. Bailey, M. Murray, L. Cooper, D. Wood, E. McQuilten, Z. Westbrook, A. Pettilä, V. Nichol, A. Bailey, M. Wood, E. Syres, G. Phillips, L. Street, A. French, C. Murray, L. Orford, N. Santamaria, J. Bellomo, R. Nichol, A. Street, A. Vallance, S. McArthur, C. McGuiness, S. Newby, L. Simmonds, C. Parke, R. Buhr, H. Bellomo, R. Goldsmith, D. O'Sullivan, K. Mercer, I. Gazzard, R. Tauschke, C. Hill, D. Fletcher, J. Boschert, C. Koch, G. Ernest, D. Eliott, S. Howe, B. Hawker, F. Ellem, K. Duff, K. Henderson, S. Mehrtens, J. Milliss, D. Wong, H. Arora, S. O'Bree, B. Shepherd, K. Ihle, B. Ho, S. Ihle, B. Graan, M. Bernsten, A. Ryan, E. Botha, J. Vuat, J. Orford, N. Kinmonth, A. Fraser, M. Richards, B. Tallott, M. Whitbread, R. Freebairn, R. Thomas, L. Parr, M. Micallef, S. Deshpande, K. Wood, J. Williams, Teresa Tai, J. Boase, A. Arora, S. Galt, P. King, B. Price, R. Tomlinson, J. Cole, L. Seppelt, I. Weisbrodt, L. Gresham, R. Nikas, M. Laing, J. Bell, J. McHugh, G. Hancock, D. Kirkham, S. Shehabi, Y. Campbell, M. Background and objectives: The timing of blood administration in critically ill patients is first driven by patients' needs. This study aimed to define the epidemiology and significance of overnight transfusion in critically ill patients. Materials and methods: This is a post hoc analysis of a prospective multicentre observational study including 874 critically ill patients receiving red blood cells, platelets, fresh frozen plasma (FFP) or cryoprecipitate. Characteristics of patients receiving blood only during the day (8 am up until 8 pm) were compared to those receiving blood only overnight (8 pm up until 8 am). Characteristics of transfusion were compared, and factors independently associated with major bleeding were analysed. Results: The 287 patients transfused during the day only had similar severity and mortality to the 258 receiving blood products overnight only. Although bleeding-related admission diagnoses were similar, major bleeding was the indication for transfusion in 12% of patients transfused in daytime only versus 30% of patients transfused at night only (P < 0·001). Similar total amount of blood products were transfused at day and night (2856 versus 2927); however, patients were more likely to receive FFP and cryoprecipitate at night compared with daytime. Overnight transfusion was independently associated with increased odds of major bleeding (odds ratio, 3·16, 95% confidence interval, 2·00–5·01). Conclusion: Transfusion occurs evenly across day and night in ICU; nonetheless, there are differences in type of blood products administered that reflect differences in indication. Critically ill patients were more likely to receive blood for major bleeding at night irrespective of admission diagnosis. 2018 Journal Article http://hdl.handle.net/20.500.11937/74033 10.1111/vox.12635 restricted
spellingShingle	Aubron, C. Kandane-Rathnayake, R. Andrianopoulos, N. Westbrook, A. Engelbrecht, S. Ozolins, I. Bailey, M. Murray, L. Cooper, D. Wood, E. McQuilten, Z. Westbrook, A. Pettilä, V. Nichol, A. Bailey, M. Wood, E. Syres, G. Phillips, L. Street, A. French, C. Murray, L. Orford, N. Santamaria, J. Bellomo, R. Nichol, A. Street, A. Vallance, S. McArthur, C. McGuiness, S. Newby, L. Simmonds, C. Parke, R. Buhr, H. Bellomo, R. Goldsmith, D. O'Sullivan, K. Mercer, I. Gazzard, R. Tauschke, C. Hill, D. Fletcher, J. Boschert, C. Koch, G. Ernest, D. Eliott, S. Howe, B. Hawker, F. Ellem, K. Duff, K. Henderson, S. Mehrtens, J. Milliss, D. Wong, H. Arora, S. O'Bree, B. Shepherd, K. Ihle, B. Ho, S. Ihle, B. Graan, M. Bernsten, A. Ryan, E. Botha, J. Vuat, J. Orford, N. Kinmonth, A. Fraser, M. Richards, B. Tallott, M. Whitbread, R. Freebairn, R. Thomas, L. Parr, M. Micallef, S. Deshpande, K. Wood, J. Williams, Teresa Tai, J. Boase, A. Arora, S. Galt, P. King, B. Price, R. Tomlinson, J. Cole, L. Seppelt, I. Weisbrodt, L. Gresham, R. Nikas, M. Laing, J. Bell, J. McHugh, G. Hancock, D. Kirkham, S. Shehabi, Y. Campbell, M. Day or overnight transfusion in critically ill patients: does it matter?
title	Day or overnight transfusion in critically ill patients: does it matter?
title_full	Day or overnight transfusion in critically ill patients: does it matter?
title_fullStr	Day or overnight transfusion in critically ill patients: does it matter?
title_full_unstemmed	Day or overnight transfusion in critically ill patients: does it matter?
title_short	Day or overnight transfusion in critically ill patients: does it matter?
title_sort	day or overnight transfusion in critically ill patients: does it matter?
url	http://hdl.handle.net/20.500.11937/74033

Day or overnight transfusion in critically ill patients: does it matter?

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