Optimized PID control of propofol and remifentanil coadministration for general anesthesia
© 2018 Elsevier B.V. A closed-loop control system for the control of the depth of hypnosis in anesthesia by using propofol-remifentanil coadministration and the Bispectral Index as feedback signal is proposed. A PID controller is employed together with a fixed ratio between propofol and remifentanil...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier
2019
|
| Online Access: | http://hdl.handle.net/20.500.11937/73977 |
| _version_ | 1848763147546001408 |
|---|---|
| author | Merigo, L. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. |
| author_facet | Merigo, L. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. |
| author_sort | Merigo, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Elsevier B.V. A closed-loop control system for the control of the depth of hypnosis in anesthesia by using propofol-remifentanil coadministration and the Bispectral Index as feedback signal is proposed. A PID controller is employed together with a fixed ratio between propofol and remifentanil infusions. The ratio allows the anesthesiologist to control the opioid-hypnotic balance during surgery. Optimal tuning rules for the proposed controller are obtained off-line by using the particle swarm optimization method and by considering a given dataset of patients and a wide range of infusion ratios that covers a rich set of scenarios that might occur in clinical practice. Finally, a gain scheduling strategy guarantees the optimality of the performance both for the induction and the maintenance phase. A Monte Carlo approach is used to evaluate the robustness of the method with respect to intra- and inter-patient variability. |
| first_indexed | 2025-11-14T10:58:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-73977 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:58:50Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-739772019-02-19T04:27:58Z Optimized PID control of propofol and remifentanil coadministration for general anesthesia Merigo, L. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. © 2018 Elsevier B.V. A closed-loop control system for the control of the depth of hypnosis in anesthesia by using propofol-remifentanil coadministration and the Bispectral Index as feedback signal is proposed. A PID controller is employed together with a fixed ratio between propofol and remifentanil infusions. The ratio allows the anesthesiologist to control the opioid-hypnotic balance during surgery. Optimal tuning rules for the proposed controller are obtained off-line by using the particle swarm optimization method and by considering a given dataset of patients and a wide range of infusion ratios that covers a rich set of scenarios that might occur in clinical practice. Finally, a gain scheduling strategy guarantees the optimality of the performance both for the induction and the maintenance phase. A Monte Carlo approach is used to evaluate the robustness of the method with respect to intra- and inter-patient variability. 2019 Journal Article http://hdl.handle.net/20.500.11937/73977 10.1016/j.cnsns.2018.12.015 Elsevier restricted |
| spellingShingle | Merigo, L. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. Optimized PID control of propofol and remifentanil coadministration for general anesthesia |
| title | Optimized PID control of propofol and remifentanil coadministration for general anesthesia |
| title_full | Optimized PID control of propofol and remifentanil coadministration for general anesthesia |
| title_fullStr | Optimized PID control of propofol and remifentanil coadministration for general anesthesia |
| title_full_unstemmed | Optimized PID control of propofol and remifentanil coadministration for general anesthesia |
| title_short | Optimized PID control of propofol and remifentanil coadministration for general anesthesia |
| title_sort | optimized pid control of propofol and remifentanil coadministration for general anesthesia |
| url | http://hdl.handle.net/20.500.11937/73977 |