A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs
In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
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MDPIAG
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/73898 |
| _version_ | 1848763127218307072 |
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| author | Wong, A. Xiang, X. Ong, P. Mitchell, E. Syn, N. Wee, I. Kumar, Alan Prem Yong, W. Sethi, G. Goh, B. Ho, P. Wang, L. |
| author_facet | Wong, A. Xiang, X. Ong, P. Mitchell, E. Syn, N. Wee, I. Kumar, Alan Prem Yong, W. Sethi, G. Goh, B. Ho, P. Wang, L. |
| author_sort | Wong, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation. |
| first_indexed | 2025-11-14T10:58:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-73898 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:58:31Z |
| publishDate | 2018 |
| publisher | MDPIAG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-738982019-03-14T01:41:20Z A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs Wong, A. Xiang, X. Ong, P. Mitchell, E. Syn, N. Wee, I. Kumar, Alan Prem Yong, W. Sethi, G. Goh, B. Ho, P. Wang, L. In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation. 2018 Journal Article http://hdl.handle.net/20.500.11937/73898 10.3390/pharmaceutics10040221 http://creativecommons.org/licenses/by/4.0/ MDPIAG fulltext |
| spellingShingle | Wong, A. Xiang, X. Ong, P. Mitchell, E. Syn, N. Wee, I. Kumar, Alan Prem Yong, W. Sethi, G. Goh, B. Ho, P. Wang, L. A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs |
| title | A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs |
| title_full | A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs |
| title_fullStr | A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs |
| title_full_unstemmed | A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs |
| title_short | A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs |
| title_sort | review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs |
| url | http://hdl.handle.net/20.500.11937/73898 |