Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease
© 2019 Elsevier Inc. The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's diseas...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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Elsevier Inc.
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/73742 |
| _version_ | 1848763086288191488 |
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| author | Porter, T. Burnham, S. Milicic, L. Savage, G. Maruff, P. Lim, Y. Ames, D. Masters, C. Martins, R. Rainey-Smith, S. Rowe, C. Salvado, O. Groth, David Verdile, Giuseppe Villemagne, V. Laws, S. |
| author_facet | Porter, T. Burnham, S. Milicic, L. Savage, G. Maruff, P. Lim, Y. Ames, D. Masters, C. Martins, R. Rainey-Smith, S. Rowe, C. Salvado, O. Groth, David Verdile, Giuseppe Villemagne, V. Laws, S. |
| author_sort | Porter, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2019 Elsevier Inc. The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-ß (Aß) burden, and carriage of the apolipoprotein E (APOE) e4 allele on cognitive decline. This study involved 581 Aß-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aß burden and APOE e4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aß burden and APOE e4–driven cognitive decline in preclinical AD. |
| first_indexed | 2025-11-14T10:57:52Z |
| format | Journal Article |
| id | curtin-20.500.11937-73742 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:57:52Z |
| publishDate | 2019 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-737422019-02-19T04:25:45Z Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease Porter, T. Burnham, S. Milicic, L. Savage, G. Maruff, P. Lim, Y. Ames, D. Masters, C. Martins, R. Rainey-Smith, S. Rowe, C. Salvado, O. Groth, David Verdile, Giuseppe Villemagne, V. Laws, S. © 2019 Elsevier Inc. The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-ß (Aß) burden, and carriage of the apolipoprotein E (APOE) e4 allele on cognitive decline. This study involved 581 Aß-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aß burden and APOE e4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aß burden and APOE e4–driven cognitive decline in preclinical AD. 2019 Journal Article http://hdl.handle.net/20.500.11937/73742 10.1016/j.neurobiolaging.2018.12.014 Elsevier Inc. restricted |
| spellingShingle | Porter, T. Burnham, S. Milicic, L. Savage, G. Maruff, P. Lim, Y. Ames, D. Masters, C. Martins, R. Rainey-Smith, S. Rowe, C. Salvado, O. Groth, David Verdile, Giuseppe Villemagne, V. Laws, S. Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease |
| title | Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease |
| title_full | Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease |
| title_fullStr | Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease |
| title_full_unstemmed | Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease |
| title_short | Klotho allele status is not associated with Aß and APOE e4–related cognitive decline in preclinical Alzheimer's disease |
| title_sort | klotho allele status is not associated with aß and apoe e4–related cognitive decline in preclinical alzheimer's disease |
| url | http://hdl.handle.net/20.500.11937/73742 |