The Interaction of Insulin with the Insulin Receptor in a Membrane Environment
The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cel...
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| Format: | Thesis |
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Curtin University
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/73527 |
| _version_ | 1848762287846850560 |
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| author | Sabapathy, Thiruvarutchelvan |
| author_facet | Sabapathy, Thiruvarutchelvan |
| author_sort | Sabapathy, Thiruvarutchelvan |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cell plasma membranes. The study is of relevance to a better understanding of diabetes at a molecular level. Novel results include the demonstration that alterations in membrane cholesterol content significantly reduce insulin binding and signalling. |
| first_indexed | 2025-11-14T10:45:10Z |
| format | Thesis |
| id | curtin-20.500.11937-73527 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:45:10Z |
| publishDate | 2018 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-735272019-12-17T02:37:47Z The Interaction of Insulin with the Insulin Receptor in a Membrane Environment Sabapathy, Thiruvarutchelvan The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cell plasma membranes. The study is of relevance to a better understanding of diabetes at a molecular level. Novel results include the demonstration that alterations in membrane cholesterol content significantly reduce insulin binding and signalling. 2018 Thesis http://hdl.handle.net/20.500.11937/73527 Curtin University fulltext |
| spellingShingle | Sabapathy, Thiruvarutchelvan The Interaction of Insulin with the Insulin Receptor in a Membrane Environment |
| title | The Interaction of Insulin with the Insulin Receptor in a Membrane Environment |
| title_full | The Interaction of Insulin with the Insulin Receptor in a Membrane Environment |
| title_fullStr | The Interaction of Insulin with the Insulin Receptor in a Membrane Environment |
| title_full_unstemmed | The Interaction of Insulin with the Insulin Receptor in a Membrane Environment |
| title_short | The Interaction of Insulin with the Insulin Receptor in a Membrane Environment |
| title_sort | interaction of insulin with the insulin receptor in a membrane environment |
| url | http://hdl.handle.net/20.500.11937/73527 |