The Interaction of Insulin with the Insulin Receptor in a Membrane Environment
The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cel...
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| Format: | Thesis |
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Curtin University
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/73527 |
| Summary: | The first event in insulin action is the binding of insulin to insulin-receptors embedded in the cell membrane. This study investigated how plasma membrane cholesterol influences this interaction, as examined in several experimental models including cultured cells, virus-like-particles and liver cell plasma membranes. The study is of relevance to a better understanding of diabetes at a molecular level. Novel results include the demonstration that alterations in membrane cholesterol content significantly reduce insulin binding and signalling. |
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