Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis
© 2018 The Royal College of Psychiatrists. Background: Evidence about the effect of intrauterine exposure to preeclampsiaon offspring autism-spectrum disorder (ASD) is notwell established.Aims: To examine the association between pre-eclampsia and ASD.Method: PubMed, Embase and PsycINFO databases wer...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Royal College of Psychiatrists
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/73410 |
| _version_ | 1848763006432837632 |
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| author | Dachew, B. Mamun, A. Maravilla, J. Alati, Rosa |
| author_facet | Dachew, B. Mamun, A. Maravilla, J. Alati, Rosa |
| author_sort | Dachew, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 The Royal College of Psychiatrists. Background: Evidence about the effect of intrauterine exposure to preeclampsiaon offspring autism-spectrum disorder (ASD) is notwell established.Aims: To examine the association between pre-eclampsia and ASD.Method: PubMed, Embase and PsycINFO databases were searched.Pooled relative risks (RR) with 95% confidence intervals werecalculated. Subgroup and sensitivity analyses were performed.Heterogeneity was assessed using Cochran's Q- and the I2-test.The presence of publication bias was evaluated by Egger's testand visual inspection of the symmetry in funnel plots.Results: Ten studies meet the inclusion criteria. The risk of ASD was 32%higher in offspring who had intrauterine exposure to preeclampsiacompared with those not exposed (RR = 1.32, 95% CI1.20-1.45). Sensitivity analysis revealed consistent pooled estimatesranging from RR = 1.30 (95% CI 1.17-1.44) to RR = 1.37(95% CI 1.26-1.48). We found no significant heterogeneity andevidence of publication bias. Conclusion: Pre-eclampsia increased the risk of ASD in offspring. The findingsuggests a need for early screening for ASD in offspring ofwomen with pre-eclampsia. |
| first_indexed | 2025-11-14T10:56:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-73410 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:56:36Z |
| publishDate | 2018 |
| publisher | Royal College of Psychiatrists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-734102018-12-13T09:35:32Z Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis Dachew, B. Mamun, A. Maravilla, J. Alati, Rosa © 2018 The Royal College of Psychiatrists. Background: Evidence about the effect of intrauterine exposure to preeclampsiaon offspring autism-spectrum disorder (ASD) is notwell established.Aims: To examine the association between pre-eclampsia and ASD.Method: PubMed, Embase and PsycINFO databases were searched.Pooled relative risks (RR) with 95% confidence intervals werecalculated. Subgroup and sensitivity analyses were performed.Heterogeneity was assessed using Cochran's Q- and the I2-test.The presence of publication bias was evaluated by Egger's testand visual inspection of the symmetry in funnel plots.Results: Ten studies meet the inclusion criteria. The risk of ASD was 32%higher in offspring who had intrauterine exposure to preeclampsiacompared with those not exposed (RR = 1.32, 95% CI1.20-1.45). Sensitivity analysis revealed consistent pooled estimatesranging from RR = 1.30 (95% CI 1.17-1.44) to RR = 1.37(95% CI 1.26-1.48). We found no significant heterogeneity andevidence of publication bias. Conclusion: Pre-eclampsia increased the risk of ASD in offspring. The findingsuggests a need for early screening for ASD in offspring ofwomen with pre-eclampsia. 2018 Journal Article http://hdl.handle.net/20.500.11937/73410 10.1192/bjp.2017.27 Royal College of Psychiatrists restricted |
| spellingShingle | Dachew, B. Mamun, A. Maravilla, J. Alati, Rosa Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis |
| title | Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis |
| title_full | Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis |
| title_fullStr | Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis |
| title_full_unstemmed | Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis |
| title_short | Pre-eclampsia and the risk of autism-spectrum disorder in offspring: Meta-analysis |
| title_sort | pre-eclampsia and the risk of autism-spectrum disorder in offspring: meta-analysis |
| url | http://hdl.handle.net/20.500.11937/73410 |