A new measure of decompression sickness in the rat
In this study we assessed the reliability of a tilting-board grip score as a measure of decompression sickness in rats. In experiments using a hyperbaric compression/decompression protocol, rats were observed for signs of decompression sickness and their grip strength measured on a tilting particle...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Hindawi Publishing Corporation
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/73366 |
| _version_ | 1848762995897794560 |
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| author | Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Mansourati, J. Guerrero, F. |
| author_facet | Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Mansourati, J. Guerrero, F. |
| author_sort | Buzzacott, Peter |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this study we assessed the reliability of a tilting-board grip score as a measure of decompression sickness in rats. In experiments using a hyperbaric compression/decompression protocol, rats were observed for signs of decompression sickness and their grip strength measured on a tilting particle board hinged to a metal frame. Angles at which rats lost grip were converted to gravitational vectors. Decreased mean grip scores following decompression were fitted to a logistic regression model with strain, age, and weight. Decrease in grip score was significantly associated with observed decompression sickness (P=0.0036). The log odds ratio for decompression sickness = 1.40 (decrease in grip score). In rats with no decrease in mean grip score there was a 50% probability of decompression sickness (pDCS). This increased steadily with decreases in mean grip score. A decrease of 0.3 had a 60% pDCS, a decrease of 0.6 had a 70% pDCS, and a decrease of 2.1 had a 95% pDCS. The tilting board grip score is a reliable measure of the probability of decompression sickness. © 2014 Peter Buzzacott et al. |
| first_indexed | 2025-11-14T10:56:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-73366 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:56:26Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-733662018-12-13T09:35:31Z A new measure of decompression sickness in the rat Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Mansourati, J. Guerrero, F. In this study we assessed the reliability of a tilting-board grip score as a measure of decompression sickness in rats. In experiments using a hyperbaric compression/decompression protocol, rats were observed for signs of decompression sickness and their grip strength measured on a tilting particle board hinged to a metal frame. Angles at which rats lost grip were converted to gravitational vectors. Decreased mean grip scores following decompression were fitted to a logistic regression model with strain, age, and weight. Decrease in grip score was significantly associated with observed decompression sickness (P=0.0036). The log odds ratio for decompression sickness = 1.40 (decrease in grip score). In rats with no decrease in mean grip score there was a 50% probability of decompression sickness (pDCS). This increased steadily with decreases in mean grip score. A decrease of 0.3 had a 60% pDCS, a decrease of 0.6 had a 70% pDCS, and a decrease of 2.1 had a 95% pDCS. The tilting board grip score is a reliable measure of the probability of decompression sickness. © 2014 Peter Buzzacott et al. 2014 Journal Article http://hdl.handle.net/20.500.11937/73366 10.1155/2014/123581 Hindawi Publishing Corporation restricted |
| spellingShingle | Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Mansourati, J. Guerrero, F. A new measure of decompression sickness in the rat |
| title | A new measure of decompression sickness in the rat |
| title_full | A new measure of decompression sickness in the rat |
| title_fullStr | A new measure of decompression sickness in the rat |
| title_full_unstemmed | A new measure of decompression sickness in the rat |
| title_short | A new measure of decompression sickness in the rat |
| title_sort | new measure of decompression sickness in the rat |
| url | http://hdl.handle.net/20.500.11937/73366 |