Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

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Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

Quinazolinone-based anticancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors. The steroidal AB-ring system was mimicked, favoring conformations with an...

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Bibliographic Details
Main Authors:	Dohle, W., Jourdan, Fred, Menchon, G., Prota, A., Foster, P., Mannion, P., Hamel, E., Thomas, M., Kasprzyk, P., Ferrandis, E., Steinmetz, M., Leese, M., Potter, B.
Format:	Journal Article
Published:	American Chemical Society 2018
Online Access:	http://hdl.handle.net/20.500.11937/73343

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