Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy
© 2018 Royal Pharmaceutical Society Objectives: Pigment epithelium-derived factor (PEDF), a multifunctional endogenous glycoprotein, has a very wide range of biological actions, notably in bone homeostasis. The question has been raised regarding the place of PEDF in the treatment of bone disorders a...
| Main Authors: | Baxter-Holland, M., Dass, Crispin |
|---|---|
| Format: | Journal Article |
| Published: |
John Wiley & Sons Ltd.
2018
|
| Online Access: | http://hdl.handle.net/20.500.11937/73327 |
Similar Items
Potential of pigment epithelium-derived factor (PEDF) as a bone regenerative biopharmaceutical
by: Lee, P., et al.
Published: (2016)
by: Lee, P., et al.
Published: (2016)
Stimulation of bone regeneration with pigment epithelium-derived factor microparticles: Evidence in silico, in vitro and in vivo
by: Lee, P., et al.
Published: (2016)
by: Lee, P., et al.
Published: (2016)
Pigment Epithelium-Derived Factor: Chemistry, Structure, Biology, and Applications
by: Becerra, S.P., et al.
Published: (2012)
by: Becerra, S.P., et al.
Published: (2012)
Reduction in tumour cell invasion by pigment epithelium-derived factor is mediated by membrane type-1 matrix metalloproteinase downregulation
by: Filiz, G., et al.
Published: (2012)
by: Filiz, G., et al.
Published: (2012)
Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone
by: Alcantara, M., et al.
Published: (2014)
by: Alcantara, M., et al.
Published: (2014)
Bone morphogenetic protein-2 and bone therapy: Successes and pitfalls
by: Poon, B., et al.
Published: (2016)
by: Poon, B., et al.
Published: (2016)
Pigment Epithelium-Derived Factor as an Impending Therapeutic Agent Against Vascular Epithelial Growth Factor-Driven Tumor-Angiogenesis
by: Manalo, K., et al.
Published: (2011)
by: Manalo, K., et al.
Published: (2011)
Insulin antagonises pigment epithelium-derived factor (PEDF)-induced modulation of lineage commitment of myocytes and heterotrophic ossification
by: Carnagarin, R., et al.
Published: (2018)
by: Carnagarin, R., et al.
Published: (2018)
Pigment epithelium-derived factor as a natural matrix metalloproteinase inhibitor: a comparison with classical matrix metalloproteinase inhibitors used for cancer treatment
by: Alcantara, M., et al.
Published: (2014)
by: Alcantara, M., et al.
Published: (2014)
Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective
by: Manalo, K., et al.
Published: (2011)
by: Manalo, K., et al.
Published: (2011)
Bone drug targets
by: Dass, Crispin
Published: (2018)
by: Dass, Crispin
Published: (2018)
Pigment epithelium-derived factor and
menopause in metastatic breast cancer
by: Brook, Naomi Louise
Published: (2022)
by: Brook, Naomi Louise
Published: (2022)
Transdifferentiation of myoblasts into osteoblasts - possible use for bone therapy
by: Lin, Daphne, et al.
Published: (2017)
by: Lin, Daphne, et al.
Published: (2017)
Pigment Epithelium-derived Factor and Insulin Crosstalk in Skeletal Muscle Biology
by: Carnagarin, Revathy
Published: (2017)
by: Carnagarin, Revathy
Published: (2017)
The Role of Pigment Epithelium-derived Factor in Breast
Cancer Cell Metabolism
by: Abooshahab, Raziyeh
Published: (2025)
by: Abooshahab, Raziyeh
Published: (2025)
Current research on pharmacologic and regenerative therapies for osteoarthritis
by: Zhang, W., et al.
Published: (2016)
by: Zhang, W., et al.
Published: (2016)
Modulatory and regenerative potential of transplanted bone marrow derived mesenchymal stem cells on rifampicin-induced kidney toxicity
by: Danjuma, Lawal, et al.
Published: (2018)
by: Danjuma, Lawal, et al.
Published: (2018)
Doxorubicin: The dogma and the bone
by: Wong, J., et al.
Published: (2016)
by: Wong, J., et al.
Published: (2016)
The potential role of free chitosan in bone trauma and bone cancer management
by: Tan, M., et al.
Published: (2014)
by: Tan, M., et al.
Published: (2014)
Translation of remote control regenerative technologies for bone repair
by: Markides, Hareklea, et al.
Published: (2018)
by: Markides, Hareklea, et al.
Published: (2018)
The osteocyte: master directors of bone remodelling, mineralisation and phosphate-calcium homeostasis
by: Khalid, Kamarul Ariffin, et al.
Published: (2019)
by: Khalid, Kamarul Ariffin, et al.
Published: (2019)
Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production
by: Carnagarin, R., et al.
Published: (2016)
by: Carnagarin, R., et al.
Published: (2016)
Weak bones in diabetes mellitus - an update on pharmaceutical treatment options
by: Lin, D., et al.
Published: (2017)
by: Lin, D., et al.
Published: (2017)
The applied biochemistry of PEDF and implications for tissue homeostasis
by: Broadhead, M., et al.
Published: (2010)
by: Broadhead, M., et al.
Published: (2010)
Treatment of bone disorders with parathyroid hormone: Success and pitfalls
by: Ng, P., et al.
Published: (2016)
by: Ng, P., et al.
Published: (2016)
Doxorubicin, mesenchymal stem cell toxicity and antitumour activity: implications for clinical use
by: Baxter-Holland, M., et al.
Published: (2018)
by: Baxter-Holland, M., et al.
Published: (2018)
PEDF attenuates insulin-dependent molecular pathways of glucose homeostasis in skeletal myocytes
by: Carnagarin, R., et al.
Published: (2015)
by: Carnagarin, R., et al.
Published: (2015)
Extract of palm leaf and a composition comprising the same for increasing bone mineral density and arterial homeostasis
by: Mohamed, Suhaila, et al.
Published: (2011)
by: Mohamed, Suhaila, et al.
Published: (2011)
Breast cancer bone metastases: pathogenesis and therapeutic targets
by: Brook, Naomi, et al.
Published: (2018)
by: Brook, Naomi, et al.
Published: (2018)
Fish Bone Waste As Potential Source Of Apatite For Bone Replacement
by: Ivon, Tiew
Published: (2018)
by: Ivon, Tiew
Published: (2018)
Molecular aspects of glucose homeostasis in skeletal muscle - A focus on the molecular mechanisms of insulin resistance.
by: Carnagarin, R., et al.
Published: (2015)
by: Carnagarin, R., et al.
Published: (2015)
Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets
by: Chen, Y., et al.
Published: (2016)
by: Chen, Y., et al.
Published: (2016)
Nanoparticle-Mediated Interleukin-12 Cancer Gene Therapy
by: Hallaj-Nezhadi, S., et al.
Published: (2010)
by: Hallaj-Nezhadi, S., et al.
Published: (2010)
Bone grafting and bone graft substitutes
by: Kaveh, Kamran, et al.
Published: (2010)
by: Kaveh, Kamran, et al.
Published: (2010)
Folate-mediated macromolecule delivery across the epithelium
by: Moradi, Emilia
Published: (2012)
by: Moradi, Emilia
Published: (2012)
Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus
by: Mansur, Sity Aishah
Published: (2015)
by: Mansur, Sity Aishah
Published: (2015)
Pre-mineralisation effect of nanobiocomposite bone scaffold towards bone marrow-derived stem cells growth and differentiation
by: Chow, Yoke Yue, et al.
Published: (2019)
by: Chow, Yoke Yue, et al.
Published: (2019)
Systemic leptin administration alters callus VEGF levels and enhances bone fracture healing in wildtype and ob/ob mice
by: Wu, Z., et al.
Published: (2018)
by: Wu, Z., et al.
Published: (2018)
Bone marrow seeded bone graft versus bone graft; compact bone critical sized defect healing pattern in rabbit
by: Kaveh, Kamran, et al.
Published: (2010)
by: Kaveh, Kamran, et al.
Published: (2010)
Tricalcium phosphate/hydroxyapatite (TCP-HA) bone scaffold as potential candidate for the formation of tissue engineered bone
by: Sulaiman, Shamsul, et al.
Published: (2013)
by: Sulaiman, Shamsul, et al.
Published: (2013)
Similar Items
-
Potential of pigment epithelium-derived factor (PEDF) as a bone regenerative biopharmaceutical
by: Lee, P., et al.
Published: (2016) -
Stimulation of bone regeneration with pigment epithelium-derived factor microparticles: Evidence in silico, in vitro and in vivo
by: Lee, P., et al.
Published: (2016) -
Pigment Epithelium-Derived Factor: Chemistry, Structure, Biology, and Applications
by: Becerra, S.P., et al.
Published: (2012) -
Reduction in tumour cell invasion by pigment epithelium-derived factor is mediated by membrane type-1 matrix metalloproteinase downregulation
by: Filiz, G., et al.
Published: (2012) -
Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone
by: Alcantara, M., et al.
Published: (2014)