Comparison of ion channel inhibitor combinations for limiting secondary degeneration following partial optic nerve transection

QR Code

Comparison of ion channel inhibitor combinations for limiting secondary degeneration following partial optic nerve transection

Following neurotrauma, secondary degeneration of neurons and glia adjacent to the injury leads to further functional loss. A combination of ion channel inhibitors (lomerizine + oxATP + YM872) has been shown to be effective at limiting structural and functional loss due to secondary degeneration. Her...

Full description

Bibliographic Details
Main Authors:	Toomey, L., Bartlett, C., Majimbi, Maimuna, Gopalasingam, G., Rodger, J., Fitzgerald, Melinda
Format:	Journal Article
Published:	Springer 2018
Online Access:	http://hdl.handle.net/20.500.11937/73203

Similar Items

Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection
by: Toomey, Lilian, et al.
Published: (2019)

Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors
by: Yates, N., et al.
Published: (2017)

Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma
by: Savigni, D., et al.
Published: (2013)

Strategies to limit dysmyelination during secondary degeneration following neurotrauma
by: Fitzgerald, Melinda
Published: (2014)

Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury
by: Chiha, W., et al.
Published: (2018)

Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration
by: Ashworth, B., et al.
Published: (2016)

Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm
by: Cummins, N., et al.
Published: (2013)

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma
by: O'Hare Doig, R., et al.
Published: (2017)

Vulnerability and fate of oligodendroglia in areas of secondary degeneration following neurotrauma
by: Giacci, M., et al.
Published: (2015)

Myelin Sheath Decompaction, Axon Swelling, and Functional Loss during Chronic Secondary Degeneration in Rat Optic Nerve
by: Payne, S., et al.
Published: (2012)

Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration
by: O'Hare Doig, R., et al.
Published: (2014)

PROTECTING GLIA FROM OXIDATIVE STRESS DURING SECONDARY DEGENERATION FOLLOWING NEUROTRAUMA
by: Doig, R., et al.
Published: (2014)

Phagocytes of the transected feline optic nerve: anultrastructural study
by: Chew, Stewart
Published: (2007)

Novel combinations of ion channel inhibitors for treatment of neurotrauma
by: O'Hare Doig, R., et al.
Published: (2015)

Acute Cellular and Functional Changes With a Combinatorial Treatment of Ion Channel Inhibitors Following Spinal Cord Injury
by: O’Hare Doig, R.L., et al.
Published: (2020)

The effects of a combination of ion channel inhibitors in female rats following repeated mild traumatic brain injury
by: Mao, Yilin, et al.
Published: (2018)

Three dimensional electron microscopy reveals changing axonal and myelin morphology along normal and partially injured optic nerves
by: Giacci, M., et al.
Published: (2018)

Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment
by: Szymanski, C.R., et al.
Published: (2013)

Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury
by: Chiha, Wissam, et al.
Published: (2020)

Changes in subtypes of Ca microdomains following partial injury to the central nervous system
by: Lozic, I., et al.
Published: (2014)

The Effects of S-Allyl-Cysteine and Cannabidiol on Cerebral and Retinal Neurovascular Integrity and Cognitive Function in Type 2 Diabetes
by: Majimbi, Maimuna
Published: (2024)

Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro
by: O'Hare Doig, R., et al.
Published: (2016)

Early Proliferation Does Not Prevent the Loss of Oligodendrocyte Progenitor Cells during the Chronic Phase of Secondary Degeneration in a CNS White Matter Tract
by: Payne, S., et al.
Published: (2013)

Line intercept transect
by: Saad, Shahbudin
Published: (2011)

Differential effects of 670 and 830 nm red near infrared irradiation therapy: A comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury
by: Giacci, M., et al.
Published: (2014)

Life, death, and oxidative stress: fate mapping oligodendrocyte progenitor cells following neurotrauma
by: Giacci, M., et al.
Published: (2015)

Enabling dual cellular destinations of polymeric nanoparticles for treatment following partial injury to the central nervous system
by: Lozic, I., et al.
Published: (2016)

Oxidative stress in oligodendrocytes in the penumbra following partial injury to a CNS tract and its amelioration with 670nm light
by: Szymanski, C., et al.
Published: (2012)

Performance of parametric model for line transect data
by: Saeed, Gamil Abdulraqeb Abdullah, et al.
Published: (2020)

Efficiency of Fixed-Width Transect and Line-Transect-based Distance Sampling to Survey Red Junglefowl (Gallus gallus spadiceus) in Peninsular Malaysia
by: Azhar, B., et al.
Published: (2008)

Kernel Estimation in Line Transect Sampling for Parametric Model
by: Saeed, Gamil Abdulraqeb Abdullah, et al.
Published: (2019)

Magnetic resonance microimaging of the spinal cord in the SOD1 mouse model of amyotrophic lateral sclerosis detects motor nerve root degeneration
by: Cowin, G., et al.
Published: (2011)

Development of parametric model for ungrouped and grouped line transect data
by: Gamil Abdulraqeb, Abdullah Saeed
Published: (2021)

Model for estimating of population abundance using line transect sampling
by: Noryanti, Muhammad, et al.
Published: (2017)

A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice
by: Krishnan, V., et al.
Published: (2016)

How useful are transect surveys for studying carnivores in the tropical rainforests of Borneo?
by: John, Mathai, et al.
Published: (2013)

Retinal degeneration rat model: a study on the structural and functional changes in the retina following injection of sodium iodate
by: Koh, Avin Ee Hwan, et al.
Published: (2019)

Assessing diversity of diurnal Lepidoptera in habitat fragments: testing the efficiency of strip transects.
by: Williams , Matthew
Published: (2008)

Botanical Studies within the PABITRA Wet-Zone Transect, Viti Levu, Fiji
by: Keppel, Gunnar
Published: (2005)

Relative abundance and diversity of amphibians along an elevational transect on mount Serapi, Sarawak
by: Mohd Iqbal, Makmor.
Published: (2006)

Cannot write session to /tmp/vufind_sessions/sess_hdn950rutavg9mor1n7tse7rgd