Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes
© 2017, National Academy of Sciences. All rights reserved. Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we devel...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
National Academy of Sciences
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/73057 |
| _version_ | 1848762912333627392 |
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| author | Ludwig, B. Ludwig, S. Steffen, A. Knauf, Y. Zimerman, B. Heinke, S. Lehmann, S. Schubert, U. Schmid, J. Bleyer, M. Schönmann, U. Colton, C. Bonifacio, E. Solimena, Michele Reichel, A. Schally, A. Rotem, A. Barkai, U. Grinberg-Rashi, H. Kaup, F. Avni, Y. Jones, P. Bornstein, S. |
| author_facet | Ludwig, B. Ludwig, S. Steffen, A. Knauf, Y. Zimerman, B. Heinke, S. Lehmann, S. Schubert, U. Schmid, J. Bleyer, M. Schönmann, U. Colton, C. Bonifacio, E. Solimena, Michele Reichel, A. Schally, A. Rotem, A. Barkai, U. Grinberg-Rashi, H. Kaup, F. Avni, Y. Jones, P. Bornstein, S. |
| author_sort | Ludwig, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017, National Academy of Sciences. All rights reserved. Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions. |
| first_indexed | 2025-11-14T10:55:06Z |
| format | Journal Article |
| id | curtin-20.500.11937-73057 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:55:06Z |
| publishDate | 2017 |
| publisher | National Academy of Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-730572018-12-13T09:35:22Z Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes Ludwig, B. Ludwig, S. Steffen, A. Knauf, Y. Zimerman, B. Heinke, S. Lehmann, S. Schubert, U. Schmid, J. Bleyer, M. Schönmann, U. Colton, C. Bonifacio, E. Solimena, Michele Reichel, A. Schally, A. Rotem, A. Barkai, U. Grinberg-Rashi, H. Kaup, F. Avni, Y. Jones, P. Bornstein, S. © 2017, National Academy of Sciences. All rights reserved. Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions. 2017 Journal Article http://hdl.handle.net/20.500.11937/73057 10.1073/pnas.1708420114 National Academy of Sciences restricted |
| spellingShingle | Ludwig, B. Ludwig, S. Steffen, A. Knauf, Y. Zimerman, B. Heinke, S. Lehmann, S. Schubert, U. Schmid, J. Bleyer, M. Schönmann, U. Colton, C. Bonifacio, E. Solimena, Michele Reichel, A. Schally, A. Rotem, A. Barkai, U. Grinberg-Rashi, H. Kaup, F. Avni, Y. Jones, P. Bornstein, S. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_full | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_fullStr | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_full_unstemmed | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_short | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_sort | favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| url | http://hdl.handle.net/20.500.11937/73057 |