Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

© 2017, National Academy of Sciences. All rights reserved. Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we devel...

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Bibliographic Details
Main Authors: Ludwig, B., Ludwig, S., Steffen, A., Knauf, Y., Zimerman, B., Heinke, S., Lehmann, S., Schubert, U., Schmid, J., Bleyer, M., Schönmann, U., Colton, C., Bonifacio, E., Solimena, Michele, Reichel, A., Schally, A., Rotem, A., Barkai, U., Grinberg-Rashi, H., Kaup, F., Avni, Y., Jones, P., Bornstein, S.
Format: Journal Article
Published: National Academy of Sciences 2017
Online Access:http://hdl.handle.net/20.500.11937/73057
Description
Summary:© 2017, National Academy of Sciences. All rights reserved. Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.

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