Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC)
© 2018, Springer Nature Limited. Background/Objectives: This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by four a priori-defined dietary patterns. Subjects/Methods: In a prospective design, nutritional biomarkers (carotenoids, tocopherols, ret...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/73028 |
| _version_ | 1848762904847843328 |
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| author | Aumueller, N. Boushey, Carol Franke, A. Cooney, R. Monroe, K. Haiman, C. Wilkens, L. Kolonel, L. Le Marchand, L. Maskarinec, G. |
| author_facet | Aumueller, N. Boushey, Carol Franke, A. Cooney, R. Monroe, K. Haiman, C. Wilkens, L. Kolonel, L. Le Marchand, L. Maskarinec, G. |
| author_sort | Aumueller, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018, Springer Nature Limited. Background/Objectives: This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by four a priori-defined dietary patterns. Subjects/Methods: In a prospective design, nutritional biomarkers (carotenoids, tocopherols, retinol, and coenzyme Q10) were measured using a validated HPLC-based assay. General linear models were applied to obtain covariate-adjusted means of biomarkers for tertiles of four a priori diet quality indices: Healthy Eating Index (HEI) 2010, Alternative HEI (AHEI) 2010, Alternate Mediterranean Diet Score (aMED), and Dietary Approaches to Stop Hypertension (DASH). For a subcohort of 8367 participants within the Multiethnic Cohort (MEC), diet was assessed by a validated quantitative food frequency questionnaire in 1993–96 and serum was collected in 2001–06. Results: Participants with the highest diet-quality scores had significantly higher serum concentrations of all carotenoids, total tocopherols, and a-tocopherol, whereas ?-tocopherol was inversely associated with diet quality. Adjusted means for the lowest vs. highest tertile of HEI 2010 were 1.2 vs. 1.5 mg/L for total carotenoids, 11.4 vs. 12.3 mg/L for total tocopherols, and 1.9 vs. 1.6 mg/L for ?-tocopherol (ptrend < 0.0001). The associations for the other dietary indices were similar; no indication for sex and ethnic differences was detected. Vegetable and fruit components were major predictors of most circulating micronutrients, but most other components were also associated. Conclusions: Higher diet-quality scores measured by four a priori diet quality indices were significantly associated higher serum concentrations of carotenoids and a-tocopherol, whereas ?-tocopherol was inversely associated with diet quality. |
| first_indexed | 2025-11-14T10:54:59Z |
| format | Journal Article |
| id | curtin-20.500.11937-73028 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:54:59Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-730282018-12-13T09:35:13Z Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) Aumueller, N. Boushey, Carol Franke, A. Cooney, R. Monroe, K. Haiman, C. Wilkens, L. Kolonel, L. Le Marchand, L. Maskarinec, G. © 2018, Springer Nature Limited. Background/Objectives: This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by four a priori-defined dietary patterns. Subjects/Methods: In a prospective design, nutritional biomarkers (carotenoids, tocopherols, retinol, and coenzyme Q10) were measured using a validated HPLC-based assay. General linear models were applied to obtain covariate-adjusted means of biomarkers for tertiles of four a priori diet quality indices: Healthy Eating Index (HEI) 2010, Alternative HEI (AHEI) 2010, Alternate Mediterranean Diet Score (aMED), and Dietary Approaches to Stop Hypertension (DASH). For a subcohort of 8367 participants within the Multiethnic Cohort (MEC), diet was assessed by a validated quantitative food frequency questionnaire in 1993–96 and serum was collected in 2001–06. Results: Participants with the highest diet-quality scores had significantly higher serum concentrations of all carotenoids, total tocopherols, and a-tocopherol, whereas ?-tocopherol was inversely associated with diet quality. Adjusted means for the lowest vs. highest tertile of HEI 2010 were 1.2 vs. 1.5 mg/L for total carotenoids, 11.4 vs. 12.3 mg/L for total tocopherols, and 1.9 vs. 1.6 mg/L for ?-tocopherol (ptrend < 0.0001). The associations for the other dietary indices were similar; no indication for sex and ethnic differences was detected. Vegetable and fruit components were major predictors of most circulating micronutrients, but most other components were also associated. Conclusions: Higher diet-quality scores measured by four a priori diet quality indices were significantly associated higher serum concentrations of carotenoids and a-tocopherol, whereas ?-tocopherol was inversely associated with diet quality. 2018 Journal Article http://hdl.handle.net/20.500.11937/73028 10.1038/s41430-018-0272-1 Nature Publishing Group restricted |
| spellingShingle | Aumueller, N. Boushey, Carol Franke, A. Cooney, R. Monroe, K. Haiman, C. Wilkens, L. Kolonel, L. Le Marchand, L. Maskarinec, G. Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) |
| title | Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) |
| title_full | Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) |
| title_fullStr | Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) |
| title_full_unstemmed | Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) |
| title_short | Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) |
| title_sort | diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the multiethnic cohort study (mec) |
| url | http://hdl.handle.net/20.500.11937/73028 |