USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination

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USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination

Ubiquitin modification of the TGF-ß pathway components is emerging as a key mechanism of TGF-ß pathway regulation. To limit TGF-ß responses, TGF-ß signaling is regulated through a negative feedback loop whereby the E3 ligase SMURF2 targets the TGF-ß receptor (TßR) complex for ubiquitin-mediated degr...

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Bibliographic Details
Main Authors:	Iyengar, P., Jaynes, P., Rodon, L., Lama, D., Law, K., Lim, Y., Verma, C., Seoane, J., Eichhorn, Pieter
Format:	Journal Article
Published:	Nature Publishing Group 2015
Online Access:	http://hdl.handle.net/20.500.11937/73022

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