Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study.
AIM: Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure and function among offspring exposed to alcohol during foetal life; however, hum...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Wiley-Blackwell
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/73001 |
| _version_ | 1848762897645174784 |
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| author | Das, S. McIntyre, H. Alati, Rosa Al Mamun, A. |
| author_facet | Das, S. McIntyre, H. Alati, Rosa Al Mamun, A. |
| author_sort | Das, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | AIM: Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure and function among offspring exposed to alcohol during foetal life; however, human evidence is scarce. Thus, the present study aimed to determine the development of CKD among a cohort of 30-year-old Australian offspring whose mothers reported consumption of alcohol during pregnancy. METHODS: The study sample comprised 1626 offspring of the birth the Australia cohort study (MUSP) who serum creatinine was assessed at 30 years old and CKD was categorised from stage 1 to stage 5 based on their level of eGFR following the CKD-EPI definition. RESULTS: Seven percent (n = 111) of offspring had mild to moderate (stage 2 and 3) CKD at 30 years. The overall adjusted odds of CKD were 2.01 (95% CI 0.97 to 4.13) for offspring of moderate to heavy drinking mothers in late pregnancy, 1.60 (0.70 to 3.37) for early pregnancy and 1.18 (0.72 to 1.94) for pre-pregnancy. The association was higher for female offspring-2.69 (1.02 to 7.14) for late pregnancy and 2.95 (1.12 to 7.80) for early pregnancy. Higher but insignificant odds were found for male offspring at late pregnancy 1.44 (0.46 to 4.47) only. CONCLUSION: Maternal alcohol exposure during early and late pregnancy is associated with development of mild to moderate CKD in their offspring at 30 years. This association is stronger for female than male offspring. |
| first_indexed | 2025-11-14T10:54:52Z |
| format | Journal Article |
| id | curtin-20.500.11937-73001 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:54:52Z |
| publishDate | 2017 |
| publisher | Wiley-Blackwell |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-730012018-12-13T09:33:49Z Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. Das, S. McIntyre, H. Alati, Rosa Al Mamun, A. AIM: Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure and function among offspring exposed to alcohol during foetal life; however, human evidence is scarce. Thus, the present study aimed to determine the development of CKD among a cohort of 30-year-old Australian offspring whose mothers reported consumption of alcohol during pregnancy. METHODS: The study sample comprised 1626 offspring of the birth the Australia cohort study (MUSP) who serum creatinine was assessed at 30 years old and CKD was categorised from stage 1 to stage 5 based on their level of eGFR following the CKD-EPI definition. RESULTS: Seven percent (n = 111) of offspring had mild to moderate (stage 2 and 3) CKD at 30 years. The overall adjusted odds of CKD were 2.01 (95% CI 0.97 to 4.13) for offspring of moderate to heavy drinking mothers in late pregnancy, 1.60 (0.70 to 3.37) for early pregnancy and 1.18 (0.72 to 1.94) for pre-pregnancy. The association was higher for female offspring-2.69 (1.02 to 7.14) for late pregnancy and 2.95 (1.12 to 7.80) for early pregnancy. Higher but insignificant odds were found for male offspring at late pregnancy 1.44 (0.46 to 4.47) only. CONCLUSION: Maternal alcohol exposure during early and late pregnancy is associated with development of mild to moderate CKD in their offspring at 30 years. This association is stronger for female than male offspring. 2017 Journal Article http://hdl.handle.net/20.500.11937/73001 10.1111/nep.13206 Wiley-Blackwell restricted |
| spellingShingle | Das, S. McIntyre, H. Alati, Rosa Al Mamun, A. Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. |
| title | Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. |
| title_full | Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. |
| title_fullStr | Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. |
| title_full_unstemmed | Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. |
| title_short | Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. |
| title_sort | maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study. |
| url | http://hdl.handle.net/20.500.11937/73001 |