Anemia in hospitalized patients: an overlooked risk in medical care
© 2018 AABB BACKGROUND: This study investigated the association between nadir anemia and mortality and length of stay (LOS) in a general population of hospitalized patients. STUDY DESIGN AND METHODS: A retrospective cohort study of tertiary hospital admissions in Western Australia between July 2010...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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Wiley-Blackwell
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/72903 |
| _version_ | 1848762872981618688 |
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| author | Krishnasivam, D. Trentino, K. Burrows, S. Farmer, Shannon Picardo, S. Leahy, M. Halder, A. Chamberlain, J. Swain, S. Muthucumarana, K. Waterer, G. |
| author_facet | Krishnasivam, D. Trentino, K. Burrows, S. Farmer, Shannon Picardo, S. Leahy, M. Halder, A. Chamberlain, J. Swain, S. Muthucumarana, K. Waterer, G. |
| author_sort | Krishnasivam, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 AABB BACKGROUND: This study investigated the association between nadir anemia and mortality and length of stay (LOS) in a general population of hospitalized patients. STUDY DESIGN AND METHODS: A retrospective cohort study of tertiary hospital admissions in Western Australia between July 2010 and June 2015. Outcome measures were in-hospital mortality and LOS. RESULTS: Of 80,765 inpatients, 45,675 (56.55%) had anemia during admission. Mild and moderate/severe anemia were independently associated with increased in-hospital mortality (odds ratio [OR] 1.5, 95% confidence interval [CI] 1.36-1.86, p = 0.001; OR 2.77, 95% CI 2.32-3.30, p < 0.001, respectively). Anemia was also associated with increased LOS, demonstrating a larger effect in emergency (mild anemia—incident rate ratio [IRR] 1.52, 95% CI 1.48-1.56, p < 0.001; moderate/severe anemia—IRR 2.18, 95% CI 2.11-2.26, p < 0.001) compared to elective admissions (mild anemia—IRR 1.30, 95% CI 1.21-1.41, p < 0.001; moderate/severe anemia—IRR 1.69, 95% CI 1.55-1.83, p < 0.001). LOS was longer in patients who developed anemia during admission compared to those who had anemia on admission (IRR 1.13, 95% CI 1.10-1.17, p < 0.001). Red cell transfusion was independently associated with 2.23 times higher odds of in-hospital mortality (95% CI 1.89-2.64, p < 0.001) and 1.31 times longer LOS (95% CI 1.25-1.37, p < 0.001). CONCLUSION: More than one-third of patients not anemic on admission developed anemia during admission. Even mild anemia is independently associated with increased mortality and LOS; however, transfusion to treat anemia is an independent and additive risk factor. |
| first_indexed | 2025-11-14T10:54:29Z |
| format | Journal Article |
| id | curtin-20.500.11937-72903 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:54:29Z |
| publishDate | 2018 |
| publisher | Wiley-Blackwell |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-729032018-12-13T09:33:49Z Anemia in hospitalized patients: an overlooked risk in medical care Krishnasivam, D. Trentino, K. Burrows, S. Farmer, Shannon Picardo, S. Leahy, M. Halder, A. Chamberlain, J. Swain, S. Muthucumarana, K. Waterer, G. © 2018 AABB BACKGROUND: This study investigated the association between nadir anemia and mortality and length of stay (LOS) in a general population of hospitalized patients. STUDY DESIGN AND METHODS: A retrospective cohort study of tertiary hospital admissions in Western Australia between July 2010 and June 2015. Outcome measures were in-hospital mortality and LOS. RESULTS: Of 80,765 inpatients, 45,675 (56.55%) had anemia during admission. Mild and moderate/severe anemia were independently associated with increased in-hospital mortality (odds ratio [OR] 1.5, 95% confidence interval [CI] 1.36-1.86, p = 0.001; OR 2.77, 95% CI 2.32-3.30, p < 0.001, respectively). Anemia was also associated with increased LOS, demonstrating a larger effect in emergency (mild anemia—incident rate ratio [IRR] 1.52, 95% CI 1.48-1.56, p < 0.001; moderate/severe anemia—IRR 2.18, 95% CI 2.11-2.26, p < 0.001) compared to elective admissions (mild anemia—IRR 1.30, 95% CI 1.21-1.41, p < 0.001; moderate/severe anemia—IRR 1.69, 95% CI 1.55-1.83, p < 0.001). LOS was longer in patients who developed anemia during admission compared to those who had anemia on admission (IRR 1.13, 95% CI 1.10-1.17, p < 0.001). Red cell transfusion was independently associated with 2.23 times higher odds of in-hospital mortality (95% CI 1.89-2.64, p < 0.001) and 1.31 times longer LOS (95% CI 1.25-1.37, p < 0.001). CONCLUSION: More than one-third of patients not anemic on admission developed anemia during admission. Even mild anemia is independently associated with increased mortality and LOS; however, transfusion to treat anemia is an independent and additive risk factor. 2018 Journal Article http://hdl.handle.net/20.500.11937/72903 10.1111/trf.14877 Wiley-Blackwell restricted |
| spellingShingle | Krishnasivam, D. Trentino, K. Burrows, S. Farmer, Shannon Picardo, S. Leahy, M. Halder, A. Chamberlain, J. Swain, S. Muthucumarana, K. Waterer, G. Anemia in hospitalized patients: an overlooked risk in medical care |
| title | Anemia in hospitalized patients: an overlooked risk in medical care |
| title_full | Anemia in hospitalized patients: an overlooked risk in medical care |
| title_fullStr | Anemia in hospitalized patients: an overlooked risk in medical care |
| title_full_unstemmed | Anemia in hospitalized patients: an overlooked risk in medical care |
| title_short | Anemia in hospitalized patients: an overlooked risk in medical care |
| title_sort | anemia in hospitalized patients: an overlooked risk in medical care |
| url | http://hdl.handle.net/20.500.11937/72903 |