Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma
© 2018, © 2018 The Author(s). Published by Taylor & Francis. Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulat...
| Main Authors: | , |
|---|---|
| Format: | Journal Article |
| Published: |
2018
|
| Online Access: | http://hdl.handle.net/20.500.11937/72815 |
| _version_ | 1848762849347764224 |
|---|---|
| author | Saei, A. Eichhorn, Pieter |
| author_facet | Saei, A. Eichhorn, Pieter |
| author_sort | Saei, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018, © 2018 The Author(s). Published by Taylor & Francis. Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulator of mitogen-activated protein kinase (MAPK) pathway by targeting v-raf murine sarcoma viral oncogene homolog B (BRAF) for degradation, a process which is lost in a large proportion of BRAF mutant melanoma patients, resulting in resistance to BRAF inhibitor therapies. |
| first_indexed | 2025-11-14T10:54:06Z |
| format | Journal Article |
| id | curtin-20.500.11937-72815 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:54:06Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-728152018-12-13T09:33:39Z Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma Saei, A. Eichhorn, Pieter © 2018, © 2018 The Author(s). Published by Taylor & Francis. Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulator of mitogen-activated protein kinase (MAPK) pathway by targeting v-raf murine sarcoma viral oncogene homolog B (BRAF) for degradation, a process which is lost in a large proportion of BRAF mutant melanoma patients, resulting in resistance to BRAF inhibitor therapies. 2018 Journal Article http://hdl.handle.net/20.500.11937/72815 10.1080/23723556.2018.1497862 restricted |
| spellingShingle | Saei, A. Eichhorn, Pieter Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma |
| title | Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma |
| title_full | Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma |
| title_fullStr | Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma |
| title_full_unstemmed | Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma |
| title_short | Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma |
| title_sort | ubiquitination and adaptive responses to braf inhibitors in melanoma |
| url | http://hdl.handle.net/20.500.11937/72815 |