A rat model of chronic moderate alcohol consumption and risk of decompression sickness
© 2015, South Pacific Underwater Medicine Society. All rights reserved. Introduction: This study aimed to establish if chronic, moderate, pre-dive alcohol consumption had any affect upon susceptibility to decompression sickness (DCS) in rats. Methods: A treatment group of 15 rats were given water co...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/72779 |
| _version_ | 1848762840176918528 |
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| author | Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Guerrero, F. |
| author_facet | Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Guerrero, F. |
| author_sort | Buzzacott, Peter |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2015, South Pacific Underwater Medicine Society. All rights reserved. Introduction: This study aimed to establish if chronic, moderate, pre-dive alcohol consumption had any affect upon susceptibility to decompression sickness (DCS) in rats. Methods: A treatment group of 15 rats were given water containing 12 mL·L-1 of ethanol for four weeks. Controls (n = 15) were given water. Both groups were compressed with air to 1,000 kPa, followed by staged decompression. An additional 30 control rats from a similar previous experiment were added, raising the control-treatment ratio to 3:1. Results: Rats in the treatment group consumed the equivalent of an 80 kg man drinking 2 L of 5% alcohol by volume beer per day, which is three times the recommended daily limit for men. Overall, comparing the treatment group with the combined control groups neither weight (P = 0.23) nor alcohol consumption (P = 0.69) were associated with DCS. Discussion: We observed that chronic, moderate alcohol consumption prior to compression was neither prophylactic nor deleterious for DCS in young, male rats. |
| first_indexed | 2025-11-14T10:53:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-72779 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:53:57Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-727792018-12-13T09:14:26Z A rat model of chronic moderate alcohol consumption and risk of decompression sickness Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Guerrero, F. © 2015, South Pacific Underwater Medicine Society. All rights reserved. Introduction: This study aimed to establish if chronic, moderate, pre-dive alcohol consumption had any affect upon susceptibility to decompression sickness (DCS) in rats. Methods: A treatment group of 15 rats were given water containing 12 mL·L-1 of ethanol for four weeks. Controls (n = 15) were given water. Both groups were compressed with air to 1,000 kPa, followed by staged decompression. An additional 30 control rats from a similar previous experiment were added, raising the control-treatment ratio to 3:1. Results: Rats in the treatment group consumed the equivalent of an 80 kg man drinking 2 L of 5% alcohol by volume beer per day, which is three times the recommended daily limit for men. Overall, comparing the treatment group with the combined control groups neither weight (P = 0.23) nor alcohol consumption (P = 0.69) were associated with DCS. Discussion: We observed that chronic, moderate alcohol consumption prior to compression was neither prophylactic nor deleterious for DCS in young, male rats. 2015 Journal Article http://hdl.handle.net/20.500.11937/72779 restricted |
| spellingShingle | Buzzacott, Peter Mazur, A. Wang, Q. Lambrechts, K. Theron, M. Guerrero, F. A rat model of chronic moderate alcohol consumption and risk of decompression sickness |
| title | A rat model of chronic moderate alcohol consumption and risk of decompression sickness |
| title_full | A rat model of chronic moderate alcohol consumption and risk of decompression sickness |
| title_fullStr | A rat model of chronic moderate alcohol consumption and risk of decompression sickness |
| title_full_unstemmed | A rat model of chronic moderate alcohol consumption and risk of decompression sickness |
| title_short | A rat model of chronic moderate alcohol consumption and risk of decompression sickness |
| title_sort | rat model of chronic moderate alcohol consumption and risk of decompression sickness |
| url | http://hdl.handle.net/20.500.11937/72779 |