Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet

QR Code

Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet

© The Author(s) 2018. An emerging body of evidence consistently suggests that compromised blood–brain barrier integrity may be causally associated with cognitive decline induced by type-2 diabetes. Our previous studies demonstrated that selected anti-inflammatory/anti-oxidative agents can preserve t...

Full description

Bibliographic Details
Main Authors:	Mamo, John, Lam, Virginie, Brook, E., Mooranian, A., Al-Salami, Hani, Fimognari, N., Nesbit, M., Takechi, Ryu
Format:	Journal Article
Published:	Sherborne Gibbs Limited 2018
Online Access:	http://hdl.handle.net/20.500.11937/72669

Similar Items

Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: An implication for causal link
by: Takechi, Ryu, et al.
Published: (2017)

Probucol prevents blood-brain barrier dysfunction in wild-type mice induced by saturated fat or cholesterol feeding
by: Takechi, Ryu, et al.
Published: (2013)

Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration
by: Mamo, J., et al.
Published: (2018)

Anti-hypertensive agents do not prevent blood-brain barrier dysfunction and cognitive deficits in dietary-induced obese mice
by: Mamo, John, et al.
Published: (2017)

Long-term probucol therapy continues to suppress markers of neurovascular inflammation in a dietary induced model of cerebral capillary dysfunction
by: Takechi, Ryu, et al.
Published: (2014)

Probucol Reduces Enterocytic Amyloid-beta Relative to Chylomicron Apolipoprotein B in Mice Chronically Fed Saturated Fats
by: Takechi, Ryu, et al.
Published: (2010)

Differential Effects of High-Protein Diets Derived from Soy and Casein on Blood-Brain Barrier Integrity in Wild-type Mice
by: Snelson, Matthew, et al.
Published: (2017)

The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects
by: Mooranian, Armin, et al.
Published: (2018)

Longitudinal performance of senescence accelerated mouse prone-strain 8 (SAMP8) mice in an olfactory-visual water maze challenge
by: Lam, Virginie, et al.
Published: (2018)

An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques
by: Mooranian, Armin, et al.
Published: (2019)

Long-Term Supplementation of Microencapsulated ursodeoxycholic Acid Prevents Hypertension in a Mouse Model of Insulin Resistance:
by: Al-Salami, Hani, et al.
Published: (2016)

Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids
by: Brook, E., et al.
Published: (2019)

Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes
by: Mooranian, Armin, et al.
Published: (2018)

Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats
by: D'Alonzo, Zachary, et al.
Published: (2023)

Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus
by: Mooranian, Armin
Published: (2018)

Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer’s disease
by: Pallebage-Gamarallage, M., et al.
Published: (2015)

Innovative Microcapsules for Pancreatic ß-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis
by: Mooranian, Armin, et al.
Published: (2017)

Probucol Suppresses Enterocytic Accumulation of Amyloid-β Induced by Saturated Fat and Cholesterol Feeding
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2011)

Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid
by: Mooranian, A., et al.
Published: (2018)

The differential effects of fatty acids on enterocytic abundance of amyloid-beta
by: Galloway, Susan, et al.
Published: (2019)

Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study
by: Mooranian, A., et al.
Published: (2015)

The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study
by: Mooranian, A., et al.
Published: (2015)

An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer
by: Mooranian, Armin, et al.
Published: (2014)

Restoration of dietary-fat induced blood-brain barrier dysfunction by anti-inflammatory lipid-modulating agents
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2012)

Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses
by: Mooranian, A., et al.
Published: (2018)

Contemporary lipidomic analytics: opportunities and pitfalls
by: Giles, C., et al.
Published: (2018)

Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol
by: Mooranian, Armin, et al.
Published: (2014)

A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism.
by: Chaliha, Devahuti, et al.
Published: (2020)

Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood-brain barrier function in wild-type mice
by: Takechi, Ryusuke, et al.
Published: (2013)

Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation
by: Chaliha, Devahuti, et al.
Published: (2021)

Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk
by: Takechi, Ryu, et al.
Published: (2010)

Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment
by: Elahy, Mina, et al.
Published: (2015)

A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2012)

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic ß-cell line
by: Mooranian, A., et al.
Published: (2015)

Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes
by: Mooranian, Armin, et al.
Published: (2014)

Bio-Spectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Ageing Mouse Model
by: Fimognari, Nicholas, et al.
Published: (2018)

Detection of pinworms in conventionally maintained laboratory mice
by: Raslan, Nurul Ain Fatin, et al.
Published: (2021)

Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study).
by: Lam, Virginie, et al.
Published: (2022)

The effects of long-term saturated fat enriched diets on the brain lipidome
by: Giles, C., et al.
Published: (2016)

A systematic review of the mdma model to address social impairment in autism
by: Chaliha, D., et al.
Published: (2021)

Cannot write session to /tmp/vufind_sessions/sess_td0bvv7rd7g30r6u6e625rmttd