The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo-or he...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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MDPI AG
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/72647 |
| _version_ | 1848762806194667520 |
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| author | Arora, L. Kumar, Alan Prem Arfuso, Frank Chng, W. Sethi, G. |
| author_facet | Arora, L. Kumar, Alan Prem Arfuso, Frank Chng, W. Sethi, G. |
| author_sort | Arora, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo-or heterodimers that can translocate to the cell nucleus where they act as transcription activators. Constitutive activation of STAT3 has been found to be associated with initiation and progression of various cancers. It can exert proliferative as well as anti-apoptotic effects. This review focuses on the role of STAT3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. leukemia, lymphoma and myeloma, and briefly highlights the potential therapeutic approaches developed against STAT3 activation pathway. |
| first_indexed | 2025-11-14T10:53:25Z |
| format | Journal Article |
| id | curtin-20.500.11937-72647 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:53:25Z |
| publishDate | 2018 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-726472021-01-05T08:07:08Z The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies Arora, L. Kumar, Alan Prem Arfuso, Frank Chng, W. Sethi, G. © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo-or heterodimers that can translocate to the cell nucleus where they act as transcription activators. Constitutive activation of STAT3 has been found to be associated with initiation and progression of various cancers. It can exert proliferative as well as anti-apoptotic effects. This review focuses on the role of STAT3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. leukemia, lymphoma and myeloma, and briefly highlights the potential therapeutic approaches developed against STAT3 activation pathway. 2018 Journal Article http://hdl.handle.net/20.500.11937/72647 10.3390/cancers10090327 http://creativecommons.org/licenses/by/4.0/ MDPI AG fulltext |
| spellingShingle | Arora, L. Kumar, Alan Prem Arfuso, Frank Chng, W. Sethi, G. The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies |
| title | The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies |
| title_full | The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies |
| title_fullStr | The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies |
| title_full_unstemmed | The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies |
| title_short | The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies |
| title_sort | role of signal transducer and activator of transcription 3 (stat3) and its targeted inhibition in hematological malignancies |
| url | http://hdl.handle.net/20.500.11937/72647 |