Potential anti-inflammatory and anti-cancer properties of farnesol
© 2018 by the authors. Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, fa...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
M D P I AG
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/72550 |
| _version_ | 1848762779525185536 |
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| author | Jung, Y. Hwang, S. Sethi, G. Fan, L. Arfuso, Frank Ahn, K. |
| author_facet | Jung, Y. Hwang, S. Sethi, G. Fan, L. Arfuso, Frank Ahn, K. |
| author_sort | Jung, Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 by the authors. Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, farnesol can modulate various tumorigenic proteins and/or modulates diverse signal transduction cascades. It can also induce apoptosis and downregulate cell proliferation, angiogenesis, and cell survival. To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. In this review, we describe the potential mechanisms of action underlying the therapeutic effects of farnesol against cancers and inflammatory disorders. Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies. |
| first_indexed | 2025-11-14T10:52:59Z |
| format | Journal Article |
| id | curtin-20.500.11937-72550 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:52:59Z |
| publishDate | 2018 |
| publisher | M D P I AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-725502021-01-05T08:07:07Z Potential anti-inflammatory and anti-cancer properties of farnesol Jung, Y. Hwang, S. Sethi, G. Fan, L. Arfuso, Frank Ahn, K. © 2018 by the authors. Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, farnesol can modulate various tumorigenic proteins and/or modulates diverse signal transduction cascades. It can also induce apoptosis and downregulate cell proliferation, angiogenesis, and cell survival. To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. In this review, we describe the potential mechanisms of action underlying the therapeutic effects of farnesol against cancers and inflammatory disorders. Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies. 2018 Journal Article http://hdl.handle.net/20.500.11937/72550 10.3390/molecules23112827 http://creativecommons.org/licenses/by/4.0/ M D P I AG fulltext |
| spellingShingle | Jung, Y. Hwang, S. Sethi, G. Fan, L. Arfuso, Frank Ahn, K. Potential anti-inflammatory and anti-cancer properties of farnesol |
| title | Potential anti-inflammatory and anti-cancer properties of farnesol |
| title_full | Potential anti-inflammatory and anti-cancer properties of farnesol |
| title_fullStr | Potential anti-inflammatory and anti-cancer properties of farnesol |
| title_full_unstemmed | Potential anti-inflammatory and anti-cancer properties of farnesol |
| title_short | Potential anti-inflammatory and anti-cancer properties of farnesol |
| title_sort | potential anti-inflammatory and anti-cancer properties of farnesol |
| url | http://hdl.handle.net/20.500.11937/72550 |