Electrospinning and characterization of silk fibroin/gelatin nanofibre mats
In this study, Bombyx mori silk fibroin/gelatin (SF/GT) nanocomposite with different GT ratio (SF/GT 100/0, 90/10 and 70/30) were prepared by electrospinning process and crosslinked with glutaraldehyde (GA) vapor. Properties of crosslinked SF/GT nanocomposites were investigated by scanning electron...
| Main Authors: | , |
|---|---|
| Format: | Conference Paper |
| Published: |
World Academy of Science, Engineering and Technology
2018
|
| Online Access: | https://waset.org/abstracts/94169 http://hdl.handle.net/20.500.11937/72522 |
| _version_ | 1848762772956905472 |
|---|---|
| author | Mohammadzadehmoghadam, S. Dong, Yu |
| author_facet | Mohammadzadehmoghadam, S. Dong, Yu |
| author_sort | Mohammadzadehmoghadam, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this study, Bombyx mori silk fibroin/gelatin (SF/GT) nanocomposite with different GT ratio (SF/GT 100/0, 90/10 and 70/30) were prepared by electrospinning process and crosslinked with glutaraldehyde (GA) vapor. Properties of crosslinked SF/GT nanocomposites were investigated by scanning electron microscopy (SEM), mechanical test, water uptake capacity (WUC) and porosity. From SEM images, it was found that fiber diameter increased as GT content increased. The results of mechanical test indicated that the SF/GT 70/30 nanocomposites had both the highest Young's modulus of 342 MPa and the highest tensile strength of about 14 MPa. However, porosity and WUC decreased from 62% and 405% for pristine SF to 47% and 232% for SF/GT 70/30, respectively. This behavior can be related to higher degree of crosslinking as GT ratio increased which altered the structure and physical properties of scaffolds. This study showed that incorporation of GT into SF nanofibers can enhance mechanical properties of resultant nanocomposite, but the GA treatment should be optimized to control and fine-tune other properties to warrant their biomedical application. |
| first_indexed | 2025-11-14T10:52:53Z |
| format | Conference Paper |
| id | curtin-20.500.11937-72522 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:52:53Z |
| publishDate | 2018 |
| publisher | World Academy of Science, Engineering and Technology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-725222018-12-14T01:02:35Z Electrospinning and characterization of silk fibroin/gelatin nanofibre mats Mohammadzadehmoghadam, S. Dong, Yu In this study, Bombyx mori silk fibroin/gelatin (SF/GT) nanocomposite with different GT ratio (SF/GT 100/0, 90/10 and 70/30) were prepared by electrospinning process and crosslinked with glutaraldehyde (GA) vapor. Properties of crosslinked SF/GT nanocomposites were investigated by scanning electron microscopy (SEM), mechanical test, water uptake capacity (WUC) and porosity. From SEM images, it was found that fiber diameter increased as GT content increased. The results of mechanical test indicated that the SF/GT 70/30 nanocomposites had both the highest Young's modulus of 342 MPa and the highest tensile strength of about 14 MPa. However, porosity and WUC decreased from 62% and 405% for pristine SF to 47% and 232% for SF/GT 70/30, respectively. This behavior can be related to higher degree of crosslinking as GT ratio increased which altered the structure and physical properties of scaffolds. This study showed that incorporation of GT into SF nanofibers can enhance mechanical properties of resultant nanocomposite, but the GA treatment should be optimized to control and fine-tune other properties to warrant their biomedical application. 2018 Conference Paper http://hdl.handle.net/20.500.11937/72522 https://waset.org/abstracts/94169 World Academy of Science, Engineering and Technology restricted |
| spellingShingle | Mohammadzadehmoghadam, S. Dong, Yu Electrospinning and characterization of silk fibroin/gelatin nanofibre mats |
| title | Electrospinning and characterization of silk fibroin/gelatin nanofibre mats |
| title_full | Electrospinning and characterization of silk fibroin/gelatin nanofibre mats |
| title_fullStr | Electrospinning and characterization of silk fibroin/gelatin nanofibre mats |
| title_full_unstemmed | Electrospinning and characterization of silk fibroin/gelatin nanofibre mats |
| title_short | Electrospinning and characterization of silk fibroin/gelatin nanofibre mats |
| title_sort | electrospinning and characterization of silk fibroin/gelatin nanofibre mats |
| url | https://waset.org/abstracts/94169 http://hdl.handle.net/20.500.11937/72522 |