Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration

QR Code

Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration

© 2018 2018 Newlands Press. Aim: To enhance the bioavailability and brain uptake of probucol and examine whether it attenuates neuroinflammation and neurodegeneration by utilizing a sodium alginate nanoencapsulation technique. Materials & methods: Wild-type mice were given either low-fat standar...

Full description

Bibliographic Details
Main Authors:	Mamo, J., Lam, Virginie, Al-Salami, Hani, Brook, E., Mooranian, A., Nesbit, M., Graneri, L., D'Alonzo, Z., Fimognari, N., Stephenson, A., Takechi, Ryu
Format:	Journal Article
Published:	2018
Online Access:	http://hdl.handle.net/20.500.11937/71806

Similar Items

Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet
by: Mamo, John, et al.
Published: (2018)

Blood-brain barrier dysfunction precedes cognitive decline and neurodegeneration in diabetic insulin resistant mouse model: An implication for causal link
by: Takechi, Ryu, et al.
Published: (2017)

Long-term probucol therapy continues to suppress markers of neurovascular inflammation in a dietary induced model of cerebral capillary dysfunction
by: Takechi, Ryu, et al.
Published: (2014)

Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats
by: D'Alonzo, Zachary, et al.
Published: (2023)

Longitudinal performance of senescence accelerated mouse prone-strain 8 (SAMP8) mice in an olfactory-visual water maze challenge
by: Lam, Virginie, et al.
Published: (2018)

Probucol Suppresses Enterocytic Accumulation of Amyloid-β Induced by Saturated Fat and Cholesterol Feeding
by: Pallebage-Gamarallage, Menuka, et al.
Published: (2011)

The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects
by: Mooranian, Armin, et al.
Published: (2018)

Probucol prevents blood-brain barrier dysfunction in wild-type mice induced by saturated fat or cholesterol feeding
by: Takechi, Ryu, et al.
Published: (2013)

Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study
by: Mooranian, A., et al.
Published: (2015)

Bile acid-based micro/nano capsules for the targeted oral delivery of probucol
by: Wagle, Susbin Raj
Published: (2020)

The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress
by: Wagle, Susbin Raj
Published: (2025)

Anti-hypertensive agents do not prevent blood-brain barrier dysfunction and cognitive deficits in dietary-induced obese mice
by: Mamo, John, et al.
Published: (2017)

Probucol Reduces Enterocytic Amyloid-beta Relative to Chylomicron Apolipoprotein B in Mice Chronically Fed Saturated Fats
by: Takechi, Ryu, et al.
Published: (2010)

An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques
by: Mooranian, Armin, et al.
Published: (2019)

Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus
by: Mooranian, Armin
Published: (2018)

Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes
by: Mooranian, Armin, et al.
Published: (2018)

Long-Term Supplementation of Microencapsulated ursodeoxycholic Acid Prevents Hypertension in a Mouse Model of Insulin Resistance:
by: Al-Salami, Hani, et al.
Published: (2016)

Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid
by: Mooranian, A., et al.
Published: (2018)

Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids
by: Brook, E., et al.
Published: (2019)

The differential effects of fatty acids on enterocytic abundance of amyloid-beta
by: Galloway, Susan, et al.
Published: (2019)

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic ß-cell line
by: Mooranian, A., et al.
Published: (2015)

Dietary menhaden fish oil supplementation suppresses lipopolysaccharide-induced neuroinflammation and cognitive impairment in diabetic rats
by: Titisari, Nurina, et al.
Published: (2024)

Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol
by: Mooranian, Armin, et al.
Published: (2014)

The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study
by: Mooranian, A., et al.
Published: (2015)

An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer
by: Mooranian, Armin, et al.
Published: (2014)

Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses
by: Mooranian, A., et al.
Published: (2018)

Interactive Effects of Dietary Fat and APOE Genotype on Peripheral Amyloid-Beta: Implications for Alzheimer’s Disease Risk
by: D'Alonzo, Zachary John
Published: (2025)

Detecting neuroinflammation with molecular MRI
by: Yanez Lopez, Maria
Published: (2015)

Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells
by: Mooranian, A., et al.
Published: (2017)

Contemporary lipidomic analytics: opportunities and pitfalls
by: Giles, C., et al.
Published: (2018)

Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study).
by: Lam, Virginie, et al.
Published: (2022)

Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes
by: Mooranian, Armin, et al.
Published: (2014)

The mitochondrial basis of ageing and neurodegeneration
by: Ingram, Thomas Liam
Published: (2020)

Differential Effects of High-Protein Diets Derived from Soy and Casein on Blood-Brain Barrier Integrity in Wild-type Mice
by: Snelson, Matthew, et al.
Published: (2017)

Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation
by: Chaliha, Devahuti, et al.
Published: (2021)

Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk
by: Takechi, Ryu, et al.
Published: (2010)

Bio-Spectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Ageing Mouse Model
by: Fimognari, Nicholas, et al.
Published: (2018)

Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes
by: Negrulj, R., et al.
Published: (2015)

The role of type 2 diabetes in neurodegeneration
by: Verdile, Giuseppe, et al.
Published: (2015)

A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism.
by: Chaliha, Devahuti, et al.
Published: (2020)