Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles
© 2016 American Chemical Society. A physiologically based pharmacokinetic model was developed for accurately characterizing and predicting the in vivo fate of long-circulating inorganic nanoparticles (NPs). This model is built based on direct visualization of NP disposition details at the organ and...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
American Chemical Society
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/71707 |
| _version_ | 1848762551319396352 |
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| author | Liang, X. Wang, H. Grice, J. Li, L. Liu, Jian Xu, Z. Roberts, M. |
| author_facet | Liang, X. Wang, H. Grice, J. Li, L. Liu, Jian Xu, Z. Roberts, M. |
| author_sort | Liang, X. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2016 American Chemical Society. A physiologically based pharmacokinetic model was developed for accurately characterizing and predicting the in vivo fate of long-circulating inorganic nanoparticles (NPs). This model is built based on direct visualization of NP disposition details at the organ and cellular level. It was validated with multiple data sets, indicating robust inter-route and interspecies predictive capability. We suggest that the biodistribution of long-circulating inorganic NPs is determined by the uptake and release of NPs by phagocytic cells in target organs. |
| first_indexed | 2025-11-14T10:49:22Z |
| format | Journal Article |
| id | curtin-20.500.11937-71707 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:49:22Z |
| publishDate | 2016 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-717072018-12-13T09:32:59Z Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles Liang, X. Wang, H. Grice, J. Li, L. Liu, Jian Xu, Z. Roberts, M. © 2016 American Chemical Society. A physiologically based pharmacokinetic model was developed for accurately characterizing and predicting the in vivo fate of long-circulating inorganic nanoparticles (NPs). This model is built based on direct visualization of NP disposition details at the organ and cellular level. It was validated with multiple data sets, indicating robust inter-route and interspecies predictive capability. We suggest that the biodistribution of long-circulating inorganic NPs is determined by the uptake and release of NPs by phagocytic cells in target organs. 2016 Journal Article http://hdl.handle.net/20.500.11937/71707 10.1021/acs.nanolett.5b03854 American Chemical Society restricted |
| spellingShingle | Liang, X. Wang, H. Grice, J. Li, L. Liu, Jian Xu, Z. Roberts, M. Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles |
| title | Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles |
| title_full | Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles |
| title_fullStr | Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles |
| title_full_unstemmed | Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles |
| title_short | Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles |
| title_sort | physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles |
| url | http://hdl.handle.net/20.500.11937/71707 |