Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents
Background: There is significant evidence to suggest that psychological and stress-related factors are important predictors of the onset of chronic widespread pain (CWP) and fibromyalgia (FM). The hypothalamic-pituitary-adrenal axis, together with the efferent sympathetic/adrenomedullary system, inf...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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John Wiley & Sons Ltd.
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/7169 |
| _version_ | 1848745289039478784 |
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| author | Skouen, J. Smith, Anne Warrington, N. O'Sullivan, Peter McKenzie, Luke Pennell, C. Straker, Leon |
| author_facet | Skouen, J. Smith, Anne Warrington, N. O'Sullivan, Peter McKenzie, Luke Pennell, C. Straker, Leon |
| author_sort | Skouen, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: There is significant evidence to suggest that psychological and stress-related factors are important predictors of the onset of chronic widespread pain (CWP) and fibromyalgia (FM). The hypothalamic-pituitary-adrenal axis, together with the efferent sympathetic/adrenomedullary system, influence all body organs (including muscles) during short- and long-term threatening stimuli. The aim of this study was to investigate the relationship between genetic variants in adrenergic candidate genes and chronic musculoskeletal complaints (MSCs) in adolescents. Methods: Adolescents from the Western Australian Pregnancy (Raine) Cohort attending the 17-year cohort review completed a questionnaire containing a broad range of psychosocial factors and pain assessment (n = 1004). Blood samples were collected for DNA extraction and genotyping. Genotype data was obtained for 14 single nucleotide polymorphisms (SNPs) in two candidate genes – beta-2 adrenergic receptor (ADRB2) and catecholamine-O-methyltransferase (COMT). Haplotypes were reconstructed for all individuals with genotype data. Results and Conclusion: Both female gender and poor mental health were associated with (1) an increased risk for chronic, disabling comorbid neck and low back pain (CDCP); and (2) an increase in the number of areas of pain. Of the 14 SNPs evaluated, only SNP rs2053044 (ADRB2, recessive model) displayed an association with CDCP [odds ratio (OR) = 2.49; 95% confidence interval (CI) = 1.25, 4.98; p = 0.01] and pain in three to four pain areas in the last month (OR = 1.86; 95% CI = 1.13, 3.06; p = 0.02). These data suggest that genetic variants in ADRB2 may be involved in chronic MSCs. |
| first_indexed | 2025-11-14T06:14:59Z |
| format | Journal Article |
| id | curtin-20.500.11937-7169 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:14:59Z |
| publishDate | 2012 |
| publisher | John Wiley & Sons Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-71692017-09-13T16:01:43Z Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents Skouen, J. Smith, Anne Warrington, N. O'Sullivan, Peter McKenzie, Luke Pennell, C. Straker, Leon Background: There is significant evidence to suggest that psychological and stress-related factors are important predictors of the onset of chronic widespread pain (CWP) and fibromyalgia (FM). The hypothalamic-pituitary-adrenal axis, together with the efferent sympathetic/adrenomedullary system, influence all body organs (including muscles) during short- and long-term threatening stimuli. The aim of this study was to investigate the relationship between genetic variants in adrenergic candidate genes and chronic musculoskeletal complaints (MSCs) in adolescents. Methods: Adolescents from the Western Australian Pregnancy (Raine) Cohort attending the 17-year cohort review completed a questionnaire containing a broad range of psychosocial factors and pain assessment (n = 1004). Blood samples were collected for DNA extraction and genotyping. Genotype data was obtained for 14 single nucleotide polymorphisms (SNPs) in two candidate genes – beta-2 adrenergic receptor (ADRB2) and catecholamine-O-methyltransferase (COMT). Haplotypes were reconstructed for all individuals with genotype data. Results and Conclusion: Both female gender and poor mental health were associated with (1) an increased risk for chronic, disabling comorbid neck and low back pain (CDCP); and (2) an increase in the number of areas of pain. Of the 14 SNPs evaluated, only SNP rs2053044 (ADRB2, recessive model) displayed an association with CDCP [odds ratio (OR) = 2.49; 95% confidence interval (CI) = 1.25, 4.98; p = 0.01] and pain in three to four pain areas in the last month (OR = 1.86; 95% CI = 1.13, 3.06; p = 0.02). These data suggest that genetic variants in ADRB2 may be involved in chronic MSCs. 2012 Journal Article http://hdl.handle.net/20.500.11937/7169 10.1002/j.1532-2149.2012.00131.x John Wiley & Sons Ltd. restricted |
| spellingShingle | Skouen, J. Smith, Anne Warrington, N. O'Sullivan, Peter McKenzie, Luke Pennell, C. Straker, Leon Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents |
| title | Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents |
| title_full | Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents |
| title_fullStr | Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents |
| title_full_unstemmed | Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents |
| title_short | Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents |
| title_sort | genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents |
| url | http://hdl.handle.net/20.500.11937/7169 |