Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

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Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

© Lingzhi Wang et al. SN-38, the active metabolite of irinotecan, and histone deacetylase inhibitors (HDACis) such as belinostat, vorinostat and panobinostat, have all been shown to be deactivated by glucuronidation via UGTs. Since they all compete for UGTs for deactivation, we aimed to investigate...

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Bibliographic Details
Main Authors:	Wang, L., Chan, C., Wong, A., Wong, F., Lim, S., Chinnathambi, A., Alharbi, S., Lee, L., Soo, R., Yong, W., Lee, S., Ho, P., Sethi, Gautam, Goh, B.
Format:	Journal Article
Published:	Impact Journals LLC 2017
Online Access:	http://hdl.handle.net/20.500.11937/71606

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