Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover
The Hippo pathway has been identified as a key barrier for tumorigenesis, acting through downregulation of YAP/TAZ activity. Elevated YAP/TAZ activity has been documented in many human cancers. Ubiquitylation has been shown to play a key role in regulating YAP/TAZ activity through downregulation of...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
NATURE PUBLISHING GROUP
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/71118 |
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