Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

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Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

The Hippo pathway has been identified as a key barrier for tumorigenesis, acting through downregulation of YAP/TAZ activity. Elevated YAP/TAZ activity has been documented in many human cancers. Ubiquitylation has been shown to play a key role in regulating YAP/TAZ activity through downregulation of...

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Bibliographic Details
Main Authors:	Nguyen, H., Andrejeva, D., Gupta, R., Choudhary, C., Hong, X., Eichhorn, Pieter, Loya, A., Cohen, S.
Format:	Journal Article
Published:	NATURE PUBLISHING GROUP 2016
Online Access:	http://hdl.handle.net/20.500.11937/71118

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