Dermal contributions to human interfollicular epidermal architecture and self-renewal
© 2015 by the authors; licensee MDPI, Basel, Switzerland. The human interfollicular epidermis is renewed throughout life by populations of proliferating basal keratinocytes. Though interfollicular keratinocyte stem cells have been identified, it is not known how self-renewal in this compartment is s...
| Main Authors: | , |
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| Format: | Journal Article |
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MDPI AG
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/71077 |
| _version_ | 1848762383266217984 |
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| author | Lawlor, K. Kaur, Pritinder |
| author_facet | Lawlor, K. Kaur, Pritinder |
| author_sort | Lawlor, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2015 by the authors; licensee MDPI, Basel, Switzerland. The human interfollicular epidermis is renewed throughout life by populations of proliferating basal keratinocytes. Though interfollicular keratinocyte stem cells have been identified, it is not known how self-renewal in this compartment is spatially organized. At the epidermal-dermal junction, keratinocytes sit atop a heterogeneous mix of dermal cells that may regulate keratinocyte self-renewal by influencing local tissue architecture and signalling microenvironments. Focusing on the rete ridges and complementary dermal papillae in human skin, we review the identity and organisation of abundant dermal cells types and present evidence for interactions between the dermal microenvironment and the interfollicular keratinocytes. |
| first_indexed | 2025-11-14T10:46:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-71077 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:46:42Z |
| publishDate | 2015 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-710772021-01-08T07:54:27Z Dermal contributions to human interfollicular epidermal architecture and self-renewal Lawlor, K. Kaur, Pritinder © 2015 by the authors; licensee MDPI, Basel, Switzerland. The human interfollicular epidermis is renewed throughout life by populations of proliferating basal keratinocytes. Though interfollicular keratinocyte stem cells have been identified, it is not known how self-renewal in this compartment is spatially organized. At the epidermal-dermal junction, keratinocytes sit atop a heterogeneous mix of dermal cells that may regulate keratinocyte self-renewal by influencing local tissue architecture and signalling microenvironments. Focusing on the rete ridges and complementary dermal papillae in human skin, we review the identity and organisation of abundant dermal cells types and present evidence for interactions between the dermal microenvironment and the interfollicular keratinocytes. 2015 Journal Article http://hdl.handle.net/20.500.11937/71077 10.3390/ijms161226078 http://creativecommons.org/licenses/by/4.0/ MDPI AG fulltext |
| spellingShingle | Lawlor, K. Kaur, Pritinder Dermal contributions to human interfollicular epidermal architecture and self-renewal |
| title | Dermal contributions to human interfollicular epidermal architecture and self-renewal |
| title_full | Dermal contributions to human interfollicular epidermal architecture and self-renewal |
| title_fullStr | Dermal contributions to human interfollicular epidermal architecture and self-renewal |
| title_full_unstemmed | Dermal contributions to human interfollicular epidermal architecture and self-renewal |
| title_short | Dermal contributions to human interfollicular epidermal architecture and self-renewal |
| title_sort | dermal contributions to human interfollicular epidermal architecture and self-renewal |
| url | http://hdl.handle.net/20.500.11937/71077 |