International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study
Background: Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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BioMed Central
2018
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| Online Access: | https://ro-journal.biomedcentral.com/ http://hdl.handle.net/20.500.11937/71050 |
| _version_ | 1848762375786725376 |
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| author | Halkett, Georgia Wigley, C. Aoun, Samar Portaluri, M. Tramacere, F. Livi, L. Detti, B. Arcangeli, S. Lund, J. Kristensen, A. McFadden, N. Grun, A. Bydder, S. Sackerer, I. Greimel, E. Spry, N. EORTC Quality of Life Group |
| author_facet | Halkett, Georgia Wigley, C. Aoun, Samar Portaluri, M. Tramacere, F. Livi, L. Detti, B. Arcangeli, S. Lund, J. Kristensen, A. McFadden, N. Grun, A. Bydder, S. Sackerer, I. Greimel, E. Spry, N. EORTC Quality of Life Group |
| author_sort | Halkett, Georgia |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy. Methods: Patients (n = 358) from six countries completed the EORTC QLQ-C30, QLQ-PRT23 and EORTC Quality of Life Group debriefing questions. Clinicians completed the EORTC Radiation Therapy Oncology Group scale. Questionnaires were completed at four time-points. The module’s scale structure was examined and validated using standard psychometric analysis techniques. Results: Three items were dropped from the module (QLQ-PRT23 → QLQ-PRT20). Factor analysis identified five factors in the module: bowel control; bloating and gas; emotional function/lifestyle; pain; and leakage. Inter-item correlations were within r = 0.3–0.7. Test-Retest reliability was high. All multi-item scales discriminated between patients showing symptoms and those without symptomology. The module discriminated symptoms from the clinician completed scoring and for age, gender and comorbidities. Conclusion: The EORTC QLQ-PRT20 is designed to be used in addition to the EORTC QLQ-C30 to measure quality of life in patients who receive pelvic radiotherapy. The EORTC QLQ-PRT20 is quick to complete, acceptable to patients, has good content validity and high reliability. Trial registration: Australian and New Zealand Clinical Trials Registry (ANZCTR) ACTRN12609000972224. |
| first_indexed | 2025-11-14T10:46:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-71050 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:46:34Z |
| publishDate | 2018 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-710502019-09-24T08:15:45Z International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study Halkett, Georgia Wigley, C. Aoun, Samar Portaluri, M. Tramacere, F. Livi, L. Detti, B. Arcangeli, S. Lund, J. Kristensen, A. McFadden, N. Grun, A. Bydder, S. Sackerer, I. Greimel, E. Spry, N. EORTC Quality of Life Group Background: Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy. Methods: Patients (n = 358) from six countries completed the EORTC QLQ-C30, QLQ-PRT23 and EORTC Quality of Life Group debriefing questions. Clinicians completed the EORTC Radiation Therapy Oncology Group scale. Questionnaires were completed at four time-points. The module’s scale structure was examined and validated using standard psychometric analysis techniques. Results: Three items were dropped from the module (QLQ-PRT23 → QLQ-PRT20). Factor analysis identified five factors in the module: bowel control; bloating and gas; emotional function/lifestyle; pain; and leakage. Inter-item correlations were within r = 0.3–0.7. Test-Retest reliability was high. All multi-item scales discriminated between patients showing symptoms and those without symptomology. The module discriminated symptoms from the clinician completed scoring and for age, gender and comorbidities. Conclusion: The EORTC QLQ-PRT20 is designed to be used in addition to the EORTC QLQ-C30 to measure quality of life in patients who receive pelvic radiotherapy. The EORTC QLQ-PRT20 is quick to complete, acceptable to patients, has good content validity and high reliability. Trial registration: Australian and New Zealand Clinical Trials Registry (ANZCTR) ACTRN12609000972224. 2018 Journal Article http://hdl.handle.net/20.500.11937/71050 10.1186/s13014-018-1107-x https://ro-journal.biomedcentral.com/ http://creativecommons.org/licenses/by/4.0/ BioMed Central fulltext |
| spellingShingle | Halkett, Georgia Wigley, C. Aoun, Samar Portaluri, M. Tramacere, F. Livi, L. Detti, B. Arcangeli, S. Lund, J. Kristensen, A. McFadden, N. Grun, A. Bydder, S. Sackerer, I. Greimel, E. Spry, N. EORTC Quality of Life Group International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study |
| title | International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study |
| title_full | International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study |
| title_fullStr | International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study |
| title_full_unstemmed | International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study |
| title_short | International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study |
| title_sort | international validation of the eortc qlq-prt20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase iv study |
| url | https://ro-journal.biomedcentral.com/ http://hdl.handle.net/20.500.11937/71050 |