One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism
© 2018 Elsevier Ltd A highly selective and efficient method for the synthesis of 3,3'(5,5')-polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) was developed using the reaction of dicarboxylic acids and aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Pergamon
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/70971 |
| _version_ | 1848762354633801728 |
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| author | Lim, F. Hu, L. Tiekink, E. Dolzhenko, Anton |
| author_facet | Lim, F. Hu, L. Tiekink, E. Dolzhenko, Anton |
| author_sort | Lim, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Elsevier Ltd A highly selective and efficient method for the synthesis of 3,3'(5,5')-polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) was developed using the reaction of dicarboxylic acids and aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the desired products in good yields and purity. The scope of the method was successfully explored by the preparation of a small library of polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) with different alkyl chain linkers. The annular prototropic tautomerism in the prepared compounds was studied using NMR spectroscopy and X-ray crystallography. |
| first_indexed | 2025-11-14T10:46:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-70971 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:46:14Z |
| publishDate | 2018 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-709712018-12-13T09:32:50Z One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism Lim, F. Hu, L. Tiekink, E. Dolzhenko, Anton © 2018 Elsevier Ltd A highly selective and efficient method for the synthesis of 3,3'(5,5')-polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) was developed using the reaction of dicarboxylic acids and aminoguanidine in an aqueous medium. This one-pot, microwave-promoted method was proved to be scalable affording the desired products in good yields and purity. The scope of the method was successfully explored by the preparation of a small library of polymethylene-bis(1H-1,2,4-triazol-5(3)-amines) with different alkyl chain linkers. The annular prototropic tautomerism in the prepared compounds was studied using NMR spectroscopy and X-ray crystallography. 2018 Journal Article http://hdl.handle.net/20.500.11937/70971 10.1016/j.tetlet.2018.09.018 Pergamon restricted |
| spellingShingle | Lim, F. Hu, L. Tiekink, E. Dolzhenko, Anton One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism |
| title | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism |
| title_full | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism |
| title_fullStr | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism |
| title_full_unstemmed | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism |
| title_short | One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism |
| title_sort | one-pot, microwave-assisted synthesis of polymethylene-bridged bis(1h-1,2,4-triazol-5(3)-amines) and their tautomerism |
| url | http://hdl.handle.net/20.500.11937/70971 |