Plasmonic Janus hybrids for the detection of small metabolites
© 2018 The Royal Society of Chemistry. Advanced bio-analytical platforms rely on materials with tailored structural parameters. Herein, we assembled plasmonic Janus hybrids for laser desorption/ionization mass spectrometry (LDI MS) detection of small metabolites. We applied Janus particles (periodic...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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R S C Publications
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/70916 |
| _version_ | 1848762339408478208 |
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| author | Su, H. Liu, Ting Huang, L. Huang, J. Cao, J. Yang, H. Ye, J. Liu, Jian Qian, K. |
| author_facet | Su, H. Liu, Ting Huang, L. Huang, J. Cao, J. Yang, H. Ye, J. Liu, Jian Qian, K. |
| author_sort | Su, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 The Royal Society of Chemistry. Advanced bio-analytical platforms rely on materials with tailored structural parameters. Herein, we assembled plasmonic Janus hybrids for laser desorption/ionization mass spectrometry (LDI MS) detection of small metabolites. We applied Janus particles (periodic mesoporous organosilica (PMO) in conjunction with carbon spheres) as core materials and loaded silver nanoparticles as nanoshells. Janus core particles enhanced the LDI MS detection of both hyhrophobic and hydrophilic molecules due to anisotropic properties. Moreover, plasmonic nanoshells enabled direct metabolite detection with silver adduction in bio-mixtures, due to the selective LDI process. Furthermore, we demonstrated the tunable surface chemistry of Janus hybrids for the enrichment and identification of metabolites at low concentration (4 pM). Our work contributed to the development of tools for metabolic analysis and design of materials for bio-analytical platforms. |
| first_indexed | 2025-11-14T10:46:00Z |
| format | Journal Article |
| id | curtin-20.500.11937-70916 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:46:00Z |
| publishDate | 2018 |
| publisher | R S C Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-709162018-12-13T09:34:41Z Plasmonic Janus hybrids for the detection of small metabolites Su, H. Liu, Ting Huang, L. Huang, J. Cao, J. Yang, H. Ye, J. Liu, Jian Qian, K. © 2018 The Royal Society of Chemistry. Advanced bio-analytical platforms rely on materials with tailored structural parameters. Herein, we assembled plasmonic Janus hybrids for laser desorption/ionization mass spectrometry (LDI MS) detection of small metabolites. We applied Janus particles (periodic mesoporous organosilica (PMO) in conjunction with carbon spheres) as core materials and loaded silver nanoparticles as nanoshells. Janus core particles enhanced the LDI MS detection of both hyhrophobic and hydrophilic molecules due to anisotropic properties. Moreover, plasmonic nanoshells enabled direct metabolite detection with silver adduction in bio-mixtures, due to the selective LDI process. Furthermore, we demonstrated the tunable surface chemistry of Janus hybrids for the enrichment and identification of metabolites at low concentration (4 pM). Our work contributed to the development of tools for metabolic analysis and design of materials for bio-analytical platforms. 2018 Journal Article http://hdl.handle.net/20.500.11937/70916 10.1039/c8tb01587b R S C Publications restricted |
| spellingShingle | Su, H. Liu, Ting Huang, L. Huang, J. Cao, J. Yang, H. Ye, J. Liu, Jian Qian, K. Plasmonic Janus hybrids for the detection of small metabolites |
| title | Plasmonic Janus hybrids for the detection of small metabolites |
| title_full | Plasmonic Janus hybrids for the detection of small metabolites |
| title_fullStr | Plasmonic Janus hybrids for the detection of small metabolites |
| title_full_unstemmed | Plasmonic Janus hybrids for the detection of small metabolites |
| title_short | Plasmonic Janus hybrids for the detection of small metabolites |
| title_sort | plasmonic janus hybrids for the detection of small metabolites |
| url | http://hdl.handle.net/20.500.11937/70916 |