Regulation of the brain lipidome in health and disease
This thesis explores the plasma-brain axis in ‘Regulation of the brain lipidome in health and disease’. Using a comprehensive lipidomics platform, the main experimental objectives of this thesis were to investigate the plasma lipidome as a regulator of the cerebral lipidome. Secondary objectives wer...
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| Format: | Thesis |
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Curtin University
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/70730 |
| _version_ | 1848762289138696192 |
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| author | Giles, Corey Steven |
| author_facet | Giles, Corey Steven |
| author_sort | Giles, Corey Steven |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis explores the plasma-brain axis in ‘Regulation of the brain lipidome in health and disease’. Using a comprehensive lipidomics platform, the main experimental objectives of this thesis were to investigate the plasma lipidome as a regulator of the cerebral lipidome. Secondary objectives were to explore the potential for therapeutic modulation of sphingolipid metabolism. The experimental findings provide novel insight into regulatory mechanisms, which are informative in the context of neurodegenerative disease processes. |
| first_indexed | 2025-11-14T10:45:12Z |
| format | Thesis |
| id | curtin-20.500.11937-70730 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:45:12Z |
| publishDate | 2017 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-707302019-01-07T03:35:53Z Regulation of the brain lipidome in health and disease Giles, Corey Steven This thesis explores the plasma-brain axis in ‘Regulation of the brain lipidome in health and disease’. Using a comprehensive lipidomics platform, the main experimental objectives of this thesis were to investigate the plasma lipidome as a regulator of the cerebral lipidome. Secondary objectives were to explore the potential for therapeutic modulation of sphingolipid metabolism. The experimental findings provide novel insight into regulatory mechanisms, which are informative in the context of neurodegenerative disease processes. 2017 Thesis http://hdl.handle.net/20.500.11937/70730 Curtin University fulltext |
| spellingShingle | Giles, Corey Steven Regulation of the brain lipidome in health and disease |
| title | Regulation of the brain lipidome in health and disease |
| title_full | Regulation of the brain lipidome in health and disease |
| title_fullStr | Regulation of the brain lipidome in health and disease |
| title_full_unstemmed | Regulation of the brain lipidome in health and disease |
| title_short | Regulation of the brain lipidome in health and disease |
| title_sort | regulation of the brain lipidome in health and disease |
| url | http://hdl.handle.net/20.500.11937/70730 |