Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus
This thesis studied bile acids in the oral delivery of the anti-diabetic compound probucol as therapy for diabetes mellitus and in the application of microencapsulation of pancreatic β- cells. Bile acids improved the stability of the pharmaceutical formulation system containing probucol and enhanced...
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| Format: | Thesis |
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Curtin University
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/70687 |
| _version_ | 1848762285650083840 |
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| author | Mooranian, Armin |
| author_facet | Mooranian, Armin |
| author_sort | Mooranian, Armin |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis studied bile acids in the oral delivery of the anti-diabetic compound probucol as therapy for diabetes mellitus and in the application of microencapsulation of pancreatic β- cells. Bile acids improved the stability of the pharmaceutical formulation system containing probucol and enhanced the oral delivery resulting in greater bioavailability, tissue concentrations and glucose lowering effects in diabetic animals. Bile acids also improved the viability and activity of pancreatic β-cells within microcapsules via cellular protective effects. |
| first_indexed | 2025-11-14T10:45:08Z |
| format | Thesis |
| id | curtin-20.500.11937-70687 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:45:08Z |
| publishDate | 2018 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-706872023-12-11T03:05:05Z Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus Mooranian, Armin This thesis studied bile acids in the oral delivery of the anti-diabetic compound probucol as therapy for diabetes mellitus and in the application of microencapsulation of pancreatic β- cells. Bile acids improved the stability of the pharmaceutical formulation system containing probucol and enhanced the oral delivery resulting in greater bioavailability, tissue concentrations and glucose lowering effects in diabetic animals. Bile acids also improved the viability and activity of pancreatic β-cells within microcapsules via cellular protective effects. 2018 Thesis http://hdl.handle.net/20.500.11937/70687 Curtin University fulltext |
| spellingShingle | Mooranian, Armin Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus |
| title | Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus |
| title_full | Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus |
| title_fullStr | Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus |
| title_full_unstemmed | Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus |
| title_short | Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus |
| title_sort | novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus |
| url | http://hdl.handle.net/20.500.11937/70687 |