Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/70071 |
| _version_ | 1848762207125372928 |
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| author | Laporta-Hoyos, O. Fiori, S. Pannek, K. Ballester-Plané, J. Leiva, D. Reid, L. Pagnozzi, A. Vázquez, Élida Delgado, I. Macaya, A. Pueyo, R. Boyd, Roslyn |
| author_facet | Laporta-Hoyos, O. Fiori, S. Pannek, K. Ballester-Plané, J. Leiva, D. Reid, L. Pagnozzi, A. Vázquez, Élida Delgado, I. Macaya, A. Pueyo, R. Boyd, Roslyn |
| author_sort | Laporta-Hoyos, O. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, p <.001; B = 0.658, p <.001) and fine (B = 0.136, p =.003; B = 0.540, p <.001) motor function were associated with global sqMRI score and parietal involvement. Communication functioning was associated with putamen involvement (B = 0.747, p <.028). Intellectual functioning was associated with global sqMRI score and posterior thalamus involvement (B = -0.018, p <.001; B = -0.192, p <.001). Selective attention was associated with global sqMRI score (B = -0.035, p <.001), parietal (B = -0.063, p =.023), and corpus callosum involvement (B = -0.448, p <.001). Visuospatial and visuoperceptive abilities were associated with global sqMRI score (B = -0.078, p =.007) and medial dorsal thalamus involvement (B = -0.139, p <.012), respectively. Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI. |
| first_indexed | 2025-11-14T10:43:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-70071 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:43:54Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-700712018-12-11T05:11:30Z Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy Laporta-Hoyos, O. Fiori, S. Pannek, K. Ballester-Plané, J. Leiva, D. Reid, L. Pagnozzi, A. Vázquez, Élida Delgado, I. Macaya, A. Pueyo, R. Boyd, Roslyn To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, p <.001; B = 0.658, p <.001) and fine (B = 0.136, p =.003; B = 0.540, p <.001) motor function were associated with global sqMRI score and parietal involvement. Communication functioning was associated with putamen involvement (B = 0.747, p <.028). Intellectual functioning was associated with global sqMRI score and posterior thalamus involvement (B = -0.018, p <.001; B = -0.192, p <.001). Selective attention was associated with global sqMRI score (B = -0.035, p <.001), parietal (B = -0.063, p =.023), and corpus callosum involvement (B = -0.448, p <.001). Visuospatial and visuoperceptive abilities were associated with global sqMRI score (B = -0.078, p =.007) and medial dorsal thalamus involvement (B = -0.139, p <.012), respectively. Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI. 2018 Journal Article http://hdl.handle.net/20.500.11937/70071 10.1016/j.nicl.2018.06.015 http://creativecommons.org/licenses/by-nc-nd/4.0/ Elsevier BV fulltext |
| spellingShingle | Laporta-Hoyos, O. Fiori, S. Pannek, K. Ballester-Plané, J. Leiva, D. Reid, L. Pagnozzi, A. Vázquez, Élida Delgado, I. Macaya, A. Pueyo, R. Boyd, Roslyn Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
| title | Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
| title_full | Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
| title_fullStr | Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
| title_full_unstemmed | Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
| title_short | Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
| title_sort | brain lesion scores obtained using a simple semi-quantitative scale from mr imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy |
| url | http://hdl.handle.net/20.500.11937/70071 |