Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial

QR Code

Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial

Scope: The cardioprotective effects of apples are primarily attributed to flavonoids, found predominantly in the skin. This study aimed to determine if acute and/or chronic (4 weeks) ingestion of flavonoid-rich apples improves endothelial function, blood pressure (BP), and arterial stiffness in indi...

Full description

Bibliographic Details
Main Authors:	Bondonno, N., Bondonno, C., Blekkenhorst, L., Considine, M., Maghzal, G., Stocker, R., Woodman, R., Ward, Natalie, Hodgson, J., Croft, K.
Format:	Journal Article
Published:	Wiley - V C H Verlag GmbH 2018
Online Access:	http://hdl.handle.net/20.500.11937/70057

Similar Items

FLAVONOID-RICH APPLE IMPROVES ENDOTHELIAL FUNCTION IN INDIVIDUALS AT RISK FOR CARDIOVASCULAR DISEASE
by: Bondonno, N., et al.
Published: (2017)

Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: A randomized controlled trial
by: Bondonno, C., et al.
Published: (2012)

The cardiovascular health benefits of apples: Whole fruit vs. isolated compounds
by: Bondonno, N., et al.
Published: (2017)

The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women
by: Bondonno, C., et al.
Published: (2014)

Dietary flavonoids and nitrate: effects on nitric oxide and vascular function
by: Bondonno, C., et al.
Published: (2015)

Vegetable-derived bioactive nitrate and cardiovascular health.
by: Bondonno, C., et al.
Published: (2017)

Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: A 4-wk randomized controlled crossover trial
by: Blekkenhorst, L., et al.
Published: (2018)

The Efficacy of Quercetin in Cardiovascular Health
by: Ward, Natalie, et al.
Published: (2015)

Short-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure
by: Bondonno, C., et al.
Published: (2014)

THE ACUTE EFFECTS OF QUERCETIN-3-O-GLUCOSIDE ON ENDOTHELIAL FUNCTION AND BLOOD PRESSURE: A RANDOMIZED DOSE-RESPONSE STUDY
by: Bondonno, N., et al.
Published: (2017)

Acute effects of quercetin-3-O-glucoside on endothelial function and blood pressure: a randomized dose-response study
by: Bondonno, N., et al.
Published: (2016)

Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women
by: Hodgson, J., et al.
Published: (2016)

Nitrate, the oral microbiome, and cardiovascular health: A systematic literature review of human and animal studies
by: Blekkenhorst, L., et al.
Published: (2018)

Cardiovascular health benefits of specific vegetable types: A narrative review
by: Blekkenhorst, L., et al.
Published: (2018)

Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: A randomized controlled trial
by: Bondonno, C., et al.
Published: (2015)

LOW DOSE DIETARY NITRATE IMPROVES ENDOTHELIAL DYSFUNCTION IN THE APOE(-/-) MOUSE
by: Bakker, J., et al.
Published: (2016)

Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers
by: Liu, A., et al.
Published: (2013)

Short-term effects of a high nitrate diet on nitrate metabolism in healthy individuals
by: Bondonno, C., et al.
Published: (2015)

Development of a reference database for assessing dietary nitrate in vegetables
by: Blekkenhorst, L., et al.
Published: (2017)

Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women
by: Bondonno, C., et al.
Published: (2012)

Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein e knockout mice fed a high-fat diet: A critical role for heme oxygenase-1
by: Shen, Y., et al.
Published: (2013)

Dietary inflammatory index in relation to sub-clinical atherosclerosis and atherosclerotic vascular disease mortality in older women
by: Bondonno, N., et al.
Published: (2017)

Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE-/- mouse fed a high fat diet
by: Bakker, J., et al.
Published: (2016)

Effects of tea and coffee on cardiovascular disease risk
by: Bønn, S., et al.
Published: (2012)

Relationships of vascular function with measures of ambulatory blood pressure variation
by: Hodgson, J., et al.
Published: (2014)

Structural requirements of flavonoids to induce heme oxygenase-1 expression
by: Croft, K., et al.
Published: (2017)

Fruit intake and abdominal aortic calcification in elderly women: A prospective cohort study
by: Bondonno, N., et al.
Published: (2016)

Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women
by: Ward, Natalie, et al.
Published: (2016)

The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers
by: Boon, E., et al.
Published: (2017)

Vegetable and fruit intake and fracture-related hospitalisations: A prospective study of olderwomen
by: Blekkenhorst, L., et al.
Published: (2017)

Chlorogenic acid improves ex vivo vessel function and protects endothelial cells against HOCl-induced oxidative damage, via increased production of nitric oxide and induction of Hmox-1
by: Jiang, R., et al.
Published: (2016)

Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: Results of two randomised controlled trials
by: Hodgson, J., et al.
Published: (2014)

Citrus flavonoids in preventing cardiovascular diseases
by: Bakhtiar, M. Taher, et al.
Published: (2020)

Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet
by: Li Kwok Cheong, J., et al.
Published: (2014)

Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction
by: Ward, Natalie, et al.
Published: (2011)

Dietary nitrate and diet quality: An examination of changing dietary intakes within a representative sample of Australian women
by: Jackson, J., et al.
Published: (2018)

Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial
by: Belski, R., et al.
Published: (2011)

Tea and flavonoid intake predict osteoporotic fracture risk in elderly Australian women: A prospective study
by: Myers, G., et al.
Published: (2015)

The aging diver: Endothelial biochemistry and its potential implications for cardiovascular health
by: Ardestani, S., et al.
Published: (2015)

Pre-harvest spray application of phenylpropanoids influences accumulation of anthocyanin and flavonoids in ‘Cripps Pink’ apple skin
by: Shafiq, M., et al.
Published: (2018)