Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia
Background: Tuberculosis/HIV co-infection is a bidirectional and synergistic combination of two very important pathogens in public health. To date, there have been limited clinical data regarding mortality rates among tuberculosis/HIV co-infected patients and the impact of antiretroviral therapy on...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/69744 |
| _version_ | 1848762123249778688 |
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| author | Gesesew, H. Tsehayneh, B. Massa, D. Gebremedhin, Amanuel Tesfay Kahsay, H. Mwanri, L. |
| author_facet | Gesesew, H. Tsehayneh, B. Massa, D. Gebremedhin, Amanuel Tesfay Kahsay, H. Mwanri, L. |
| author_sort | Gesesew, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Tuberculosis/HIV co-infection is a bidirectional and synergistic combination of two very important pathogens in public health. To date, there have been limited clinical data regarding mortality rates among tuberculosis/HIV co-infected patients and the impact of antiretroviral therapy on clinical outcomes in Ethiopia. This study assessed the incidence and predictors of tuberculosis/HIV co-infection mortality in Southwest Ethiopia. Methods: A retrospective cohort study collated tuberculosis/HIV data from Jimma University Teaching Hospital for the period of September 2010 and August 2012. The data analysis used proportional hazards cox regression model at P value of ≤ 0.05 in the final model. Results: Fifty-five (20.2 %) patients died during the study period and 272 study participants contributed 3 082.7 person month observations. Factors including: being aged between 35–44 years (AHR = 2.9; 95 % CI: 1.08–7.6), being a female sex worker (AHR = 9.1; 95 % CI: 2.7–30.7), being bed ridden as functional status (AHR = 3.2; 95 % CI: 1.2–8.7), and being at World Health Organization HIV disease stages 2 (AHR = 0.2; 95 % CI: 0.06–0.5), 3(AHR = 0.3; 95 % CI: 0.1–0.8) and 4(AHR = 0.2; 95 % CI: 0.04–0.55) were significant predictors of mortality for tuberculosis/HIV co-infected patients. Conclusions: Contrary to our expectations, the World Health Organization (WHO) HIV disease stage 1 was found to be a significant predictor of mortality. Higher mortality rates were observed in WHO disease stage 1 patients compared to patients in stages 2, 3 and 4. The current study also confirmed and reaffirmed known significant predictors of the mortality for tuberculosis/HIV co-infected patients including being 35–44 years, being a female sex worker and being bed ridden functional status. The occurrence of high death rate among tuberculosis/HIV co-infected cases needs actions to reduce this poor outcome. |
| first_indexed | 2025-11-14T10:42:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-69744 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:42:34Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-697442018-10-16T06:55:36Z Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia Gesesew, H. Tsehayneh, B. Massa, D. Gebremedhin, Amanuel Tesfay Kahsay, H. Mwanri, L. Background: Tuberculosis/HIV co-infection is a bidirectional and synergistic combination of two very important pathogens in public health. To date, there have been limited clinical data regarding mortality rates among tuberculosis/HIV co-infected patients and the impact of antiretroviral therapy on clinical outcomes in Ethiopia. This study assessed the incidence and predictors of tuberculosis/HIV co-infection mortality in Southwest Ethiopia. Methods: A retrospective cohort study collated tuberculosis/HIV data from Jimma University Teaching Hospital for the period of September 2010 and August 2012. The data analysis used proportional hazards cox regression model at P value of ≤ 0.05 in the final model. Results: Fifty-five (20.2 %) patients died during the study period and 272 study participants contributed 3 082.7 person month observations. Factors including: being aged between 35–44 years (AHR = 2.9; 95 % CI: 1.08–7.6), being a female sex worker (AHR = 9.1; 95 % CI: 2.7–30.7), being bed ridden as functional status (AHR = 3.2; 95 % CI: 1.2–8.7), and being at World Health Organization HIV disease stages 2 (AHR = 0.2; 95 % CI: 0.06–0.5), 3(AHR = 0.3; 95 % CI: 0.1–0.8) and 4(AHR = 0.2; 95 % CI: 0.04–0.55) were significant predictors of mortality for tuberculosis/HIV co-infected patients. Conclusions: Contrary to our expectations, the World Health Organization (WHO) HIV disease stage 1 was found to be a significant predictor of mortality. Higher mortality rates were observed in WHO disease stage 1 patients compared to patients in stages 2, 3 and 4. The current study also confirmed and reaffirmed known significant predictors of the mortality for tuberculosis/HIV co-infected patients including being 35–44 years, being a female sex worker and being bed ridden functional status. The occurrence of high death rate among tuberculosis/HIV co-infected cases needs actions to reduce this poor outcome. 2016 Journal Article http://hdl.handle.net/20.500.11937/69744 10.1186/s40249-016-0202-1 http://creativecommons.org/licenses/by/4.0/ fulltext |
| spellingShingle | Gesesew, H. Tsehayneh, B. Massa, D. Gebremedhin, Amanuel Tesfay Kahsay, H. Mwanri, L. Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia |
| title | Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia |
| title_full | Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia |
| title_fullStr | Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia |
| title_full_unstemmed | Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia |
| title_short | Predictors of mortality in a cohort of tuberculosis/HIV co-infected patients in Southwest Ethiopia |
| title_sort | predictors of mortality in a cohort of tuberculosis/hiv co-infected patients in southwest ethiopia |
| url | http://hdl.handle.net/20.500.11937/69744 |