Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia
Background: In Australia, community-associated methicillin-resistant Staphylococcus aureus (MRSA) lineage sequence type (ST) 93 has rapidly risen to dominance since being described in the early 1990s. We examined 459 ST93 genome sequences from Australia, New Zealand, Samoa, and Europe to investigate...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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Frontiers Research Foundation
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/69714 |
| _version_ | 1848762115064594432 |
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| author | van Hal, S. Steinig, E. Andersson, P. Holden, M. Harris, S. Nimmo, G. Williamson, D. Heffernan, H. Ritchie, S. Kearns, A. Ellington, M. Dickson, E. de Lencastre, H. Coombs, Geoffrey Bentley, S. Parkhill, J. Holt, D. Giffard, P. Tong, S. |
| author_facet | van Hal, S. Steinig, E. Andersson, P. Holden, M. Harris, S. Nimmo, G. Williamson, D. Heffernan, H. Ritchie, S. Kearns, A. Ellington, M. Dickson, E. de Lencastre, H. Coombs, Geoffrey Bentley, S. Parkhill, J. Holt, D. Giffard, P. Tong, S. |
| author_sort | van Hal, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: In Australia, community-associated methicillin-resistant Staphylococcus aureus (MRSA) lineage sequence type (ST) 93 has rapidly risen to dominance since being described in the early 1990s. We examined 459 ST93 genome sequences from Australia, New Zealand, Samoa, and Europe to investigate the evolutionary history of ST93, its emergence in Australia and subsequent spread overseas. Results: Comparisons with other S. aureus genomes indicate that ST93 is an early diverging and recombinant lineage, comprising of segments from the ST59/ST121 lineage and from a divergent but currently unsampled Staphylococcal population. However, within extant ST93 strains limited genetic diversity was apparent with the most recent common ancestor dated to 1977 (95% highest posterior density 1973-1981). An epidemic ST93 population arose from a methicillin-susceptible progenitor in remote Northern Australia, which has a proportionally large Indigenous population, with documented overcrowded housing and a high burden of skin infection. Methicillin-resistance was acquired three times in these regions, with a clade harboring a staphylococcal cassette chromosome mec (SCCmec) IVa expanding and spreading to Australia's east coast by 2000. We observed sporadic and non-sustained introductions of ST93-MRSA-IVa to the United Kingdom. In contrast, in New Zealand, ST93-MRSA-IVa was sustainably transmitted with clonal expansion within the Pacific Islander population, who experience similar disadvantages as Australian Indigenous populations. Conclusion: ST93 has a highly recombinant genome including portions derived from an early diverging S. aureus population. Our findings highlight the need to understand host population factors in the emergence and spread of antimicrobial resistant community pathogens. |
| first_indexed | 2025-11-14T10:42:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-69714 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:42:26Z |
| publishDate | 2018 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-697142018-08-22T04:37:58Z Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia van Hal, S. Steinig, E. Andersson, P. Holden, M. Harris, S. Nimmo, G. Williamson, D. Heffernan, H. Ritchie, S. Kearns, A. Ellington, M. Dickson, E. de Lencastre, H. Coombs, Geoffrey Bentley, S. Parkhill, J. Holt, D. Giffard, P. Tong, S. Background: In Australia, community-associated methicillin-resistant Staphylococcus aureus (MRSA) lineage sequence type (ST) 93 has rapidly risen to dominance since being described in the early 1990s. We examined 459 ST93 genome sequences from Australia, New Zealand, Samoa, and Europe to investigate the evolutionary history of ST93, its emergence in Australia and subsequent spread overseas. Results: Comparisons with other S. aureus genomes indicate that ST93 is an early diverging and recombinant lineage, comprising of segments from the ST59/ST121 lineage and from a divergent but currently unsampled Staphylococcal population. However, within extant ST93 strains limited genetic diversity was apparent with the most recent common ancestor dated to 1977 (95% highest posterior density 1973-1981). An epidemic ST93 population arose from a methicillin-susceptible progenitor in remote Northern Australia, which has a proportionally large Indigenous population, with documented overcrowded housing and a high burden of skin infection. Methicillin-resistance was acquired three times in these regions, with a clade harboring a staphylococcal cassette chromosome mec (SCCmec) IVa expanding and spreading to Australia's east coast by 2000. We observed sporadic and non-sustained introductions of ST93-MRSA-IVa to the United Kingdom. In contrast, in New Zealand, ST93-MRSA-IVa was sustainably transmitted with clonal expansion within the Pacific Islander population, who experience similar disadvantages as Australian Indigenous populations. Conclusion: ST93 has a highly recombinant genome including portions derived from an early diverging S. aureus population. Our findings highlight the need to understand host population factors in the emergence and spread of antimicrobial resistant community pathogens. 2018 Journal Article http://hdl.handle.net/20.500.11937/69714 10.3389/fmicb.2018.01453 http://creativecommons.org/licenses/by/4.0/ Frontiers Research Foundation fulltext |
| spellingShingle | van Hal, S. Steinig, E. Andersson, P. Holden, M. Harris, S. Nimmo, G. Williamson, D. Heffernan, H. Ritchie, S. Kearns, A. Ellington, M. Dickson, E. de Lencastre, H. Coombs, Geoffrey Bentley, S. Parkhill, J. Holt, D. Giffard, P. Tong, S. Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia |
| title | Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia |
| title_full | Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia |
| title_fullStr | Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia |
| title_full_unstemmed | Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia |
| title_short | Global scale dissemination of ST93: A divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern Australia |
| title_sort | global scale dissemination of st93: a divergent staphylococcus aureus epidemic lineage that has recently emerged from remote northern australia |
| url | http://hdl.handle.net/20.500.11937/69714 |