Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression
The tumor necrosis factor (TNF)-a- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regu...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/69687 |
| _version_ | 1848762107495972864 |
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| author | Padmavathi, G. Banik, K. Monisha, J. Bordoloi, D. Shabnam, B. Arfuso, Frank Sethi, G. Fan, L. Kunnumakkara, A. |
| author_facet | Padmavathi, G. Banik, K. Monisha, J. Bordoloi, D. Shabnam, B. Arfuso, Frank Sethi, G. Fan, L. Kunnumakkara, A. |
| author_sort | Padmavathi, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The tumor necrosis factor (TNF)-a- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, inflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with the development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancreas, prostate, and thyroid gland. Also, deregulation of these proteins was found to promote the essential hallmarks of cancer such as survival, tumor growth, proliferation, inhibition of apoptosis, angiogenesis, invasion, migration, and metastasis. Further, differential expression of these proteins in normal and cancer tissues and their association with tumor progression and prognosis signifies the potential diagnostic and prognostic values of TIPE proteins and their importance in cancer therapy. The current review summarizes the literature available thus far on the expression, function, and role of TIPE proteins in the development and maintenance of various cancers. |
| first_indexed | 2025-11-14T10:42:19Z |
| format | Journal Article |
| id | curtin-20.500.11937-69687 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:42:19Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-696872018-11-14T07:41:11Z Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression Padmavathi, G. Banik, K. Monisha, J. Bordoloi, D. Shabnam, B. Arfuso, Frank Sethi, G. Fan, L. Kunnumakkara, A. The tumor necrosis factor (TNF)-a- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, inflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with the development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancreas, prostate, and thyroid gland. Also, deregulation of these proteins was found to promote the essential hallmarks of cancer such as survival, tumor growth, proliferation, inhibition of apoptosis, angiogenesis, invasion, migration, and metastasis. Further, differential expression of these proteins in normal and cancer tissues and their association with tumor progression and prognosis signifies the potential diagnostic and prognostic values of TIPE proteins and their importance in cancer therapy. The current review summarizes the literature available thus far on the expression, function, and role of TIPE proteins in the development and maintenance of various cancers. 2018 Journal Article http://hdl.handle.net/20.500.11937/69687 10.1016/j.canlet.2018.06.017 Elsevier restricted |
| spellingShingle | Padmavathi, G. Banik, K. Monisha, J. Bordoloi, D. Shabnam, B. Arfuso, Frank Sethi, G. Fan, L. Kunnumakkara, A. Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression |
| title | Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression |
| title_full | Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression |
| title_fullStr | Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression |
| title_full_unstemmed | Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression |
| title_short | Novel tumor necrosis factor-a induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression |
| title_sort | novel tumor necrosis factor-a induced protein eight (tnfaip8/tipe) family: functions and downstream targets involved in cancer progression |
| url | http://hdl.handle.net/20.500.11937/69687 |