A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination
Background: The evidence associating diet and risk of multiple sclerosis is inconclusive. Objective: We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis. Methods: We used data f...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Sage Publications Ltd.
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/69549 |
| _version_ | 1848762070426714112 |
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| author | Black, Lucinda Rowley, Charlotte Sherriff, Jill Pereira, Gavin Ponsonby, A.-L. Lucas, R. |
| author_facet | Black, Lucinda Rowley, Charlotte Sherriff, Jill Pereira, Gavin Ponsonby, A.-L. Lucas, R. |
| author_sort | Black, Lucinda |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: The evidence associating diet and risk of multiple sclerosis is inconclusive. Objective: We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis. Methods: We used data from the 2003–2006 Ausimmune Study, a case–control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Using data from a food frequency questionnaire, dietary patterns were identified using principal component analysis. Conditional logistic regression models (n = 698, 252 cases, 446 controls) were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting. Results: We identified two major dietary patterns – healthy (high in poultry, fish, eggs, vegetables, legumes) and Western (high in meat, full-fat dairy; low in wholegrains, nuts, fresh fruit, low-fat dairy), explaining 9.3% and 7.5% of variability in diet, respectively. A one-standard deviation increase in the healthy pattern score was associated with a 25% reduced risk of a first clinical diagnosis of central nervous system demyelination (adjusted odds ratio 0.75; 95% confidence interval 0.60, 0.94; p = 0.011). There was no statistically significant association between the Western dietary pattern and risk of a first clinical diagnosis of central nervous system demyelination. Conclusion: Following healthy eating guidelines may be beneficial for those at high risk of multiple sclerosis. |
| first_indexed | 2025-11-14T10:41:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-69549 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:41:43Z |
| publishDate | 2018 |
| publisher | Sage Publications Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-695492019-03-18T02:11:35Z A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination Black, Lucinda Rowley, Charlotte Sherriff, Jill Pereira, Gavin Ponsonby, A.-L. Lucas, R. Background: The evidence associating diet and risk of multiple sclerosis is inconclusive. Objective: We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis. Methods: We used data from the 2003–2006 Ausimmune Study, a case–control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Using data from a food frequency questionnaire, dietary patterns were identified using principal component analysis. Conditional logistic regression models (n = 698, 252 cases, 446 controls) were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting. Results: We identified two major dietary patterns – healthy (high in poultry, fish, eggs, vegetables, legumes) and Western (high in meat, full-fat dairy; low in wholegrains, nuts, fresh fruit, low-fat dairy), explaining 9.3% and 7.5% of variability in diet, respectively. A one-standard deviation increase in the healthy pattern score was associated with a 25% reduced risk of a first clinical diagnosis of central nervous system demyelination (adjusted odds ratio 0.75; 95% confidence interval 0.60, 0.94; p = 0.011). There was no statistically significant association between the Western dietary pattern and risk of a first clinical diagnosis of central nervous system demyelination. Conclusion: Following healthy eating guidelines may be beneficial for those at high risk of multiple sclerosis. 2018 Journal Article http://hdl.handle.net/20.500.11937/69549 10.1177/1352458518793524 Sage Publications Ltd. fulltext |
| spellingShingle | Black, Lucinda Rowley, Charlotte Sherriff, Jill Pereira, Gavin Ponsonby, A.-L. Lucas, R. A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_full | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_fullStr | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_full_unstemmed | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_short | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_sort | healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| url | http://hdl.handle.net/20.500.11937/69549 |