Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy
Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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Elsevier Science
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/69497 |
| _version_ | 1848762057442197504 |
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| author | Saeed, K. Gould, I. Espositio, S. Ahmad-Saeed, N. Ahmed, S. Alp, E. Bal, A. Bassetti, M. Bonnet, E. Chan, M. Coombs, Geoffrey Dancer, S. David, M. De Simone, G. Dryden, M. Guardabassi, L. Hanitsch, L. Hijazi, K. Krüger, R. Lee, A. Leistner, R. Pagliano, P. Righi, E. Schneider-Burrus, S. Skov, R. Tattevin, P. Van Wamel, W. Vos, M. Voss, A. |
| author_facet | Saeed, K. Gould, I. Espositio, S. Ahmad-Saeed, N. Ahmed, S. Alp, E. Bal, A. Bassetti, M. Bonnet, E. Chan, M. Coombs, Geoffrey Dancer, S. David, M. De Simone, G. Dryden, M. Guardabassi, L. Hanitsch, L. Hijazi, K. Krüger, R. Lee, A. Leistner, R. Pagliano, P. Righi, E. Schneider-Burrus, S. Skov, R. Tattevin, P. Van Wamel, W. Vos, M. Voss, A. |
| author_sort | Saeed, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research. |
| first_indexed | 2025-11-14T10:41:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-69497 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:41:31Z |
| publishDate | 2018 |
| publisher | Elsevier Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-694972018-09-27T06:29:57Z Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy Saeed, K. Gould, I. Espositio, S. Ahmad-Saeed, N. Ahmed, S. Alp, E. Bal, A. Bassetti, M. Bonnet, E. Chan, M. Coombs, Geoffrey Dancer, S. David, M. De Simone, G. Dryden, M. Guardabassi, L. Hanitsch, L. Hijazi, K. Krüger, R. Lee, A. Leistner, R. Pagliano, P. Righi, E. Schneider-Burrus, S. Skov, R. Tattevin, P. Van Wamel, W. Vos, M. Voss, A. Panton–Valentine leukocidin (PVL), a pore-forming cytotoxic secreted toxin, has been associated with severe Staphylococcus aureus pneumonia and prototypical skin lesions. The reported incidence and prevalence of PVL-positive S. aureus (PVLP-SA) varies globally and suffers from a selective reporting bias towards community-associated methicillin-resistant S. aureus (CA-MRSA). Recent studies, however, have identified PVL-positive methicillin-susceptible S. aureus (MSSA) more frequently than previously expected. In this review, a group of experts from four continents affiliated with the International Society of Chemotherapy (ISC) offer a position statement on the important aspects of PVL in S. aureus epidemiology, antimicrobial treatment and decolonisation, and aim to highlight future areas for collaboration and research. 2018 Journal Article http://hdl.handle.net/20.500.11937/69497 10.1016/j.ijantimicag.2017.11.002 Elsevier Science restricted |
| spellingShingle | Saeed, K. Gould, I. Espositio, S. Ahmad-Saeed, N. Ahmed, S. Alp, E. Bal, A. Bassetti, M. Bonnet, E. Chan, M. Coombs, Geoffrey Dancer, S. David, M. De Simone, G. Dryden, M. Guardabassi, L. Hanitsch, L. Hijazi, K. Krüger, R. Lee, A. Leistner, R. Pagliano, P. Righi, E. Schneider-Burrus, S. Skov, R. Tattevin, P. Van Wamel, W. Vos, M. Voss, A. Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy |
| title | Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy |
| title_full | Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy |
| title_fullStr | Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy |
| title_full_unstemmed | Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy |
| title_short | Panton–Valentine leukocidin-positive Staphylococcus aureus: a position statement from the International Society of Chemotherapy |
| title_sort | panton–valentine leukocidin-positive staphylococcus aureus: a position statement from the international society of chemotherapy |
| url | http://hdl.handle.net/20.500.11937/69497 |