Fatty acid metabolism complements glycolysis in th selective regulatory t cell expansion during tumor growth

Fatty acid metabolism complements glycolysis in th selective regulatory t cell expansion during tumor growth

The tumor microenvironment restrains conventional T cell (Tconv) activation while facilitating the expansion of Tregs. Here we showed that Tregs’ advantage in the tumor milieu relies on supplemental energetic routes involving lipid metabolism. In murine models, tumor-infiltrating Tregs displayed int...

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Bibliographic Details
Main Authors: Pacella, I., Procaccini, C., Focaccetti, C., Miacci, S., Timperi, E., Faicchia, D., Severa, M., Rizzo, F., Coccia, E., Bonacina, F., Mitro, N., Norata, Giuseppe, Rossetti, G., Ranzani, V., Pagani, M., Giorda, E., Wei, Y., Matarese, G., Barnaba, V., Piconese, S.
Format: Journal Article
Published: National Academy of Sciences 2018
Online Access:http://hdl.handle.net/20.500.11937/69468

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