Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling
Breast cancer is the most common cause of malignancy affecting women worldwide. This thesis focusses on the role of DDX20 in regulating Wnt/β-catenin signalling and its impact on cell fate in triple-negative breast cancer (TNBC). The results of this study demonstrated a new role for DDX20-mediated...
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| Format: | Thesis |
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Curtin University
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/69390 |
| _version_ | 1848762038019424256 |
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| author | Pohl, Sebastian Öther-Gee |
| author_facet | Pohl, Sebastian Öther-Gee |
| author_sort | Pohl, Sebastian Öther-Gee |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Breast cancer is the most common cause of malignancy affecting women worldwide. This thesis focusses on the role of DDX20 in regulating Wnt/β-catenin signalling and its impact on cell fate in triple-negative breast cancer (TNBC). The results of this study demonstrated a new role for DDX20-mediated Wnt signalling governing intracellular redox and mitochondrial function. Furthermore, we have determined that DDX20 is an essential regulator of Wnt/β-catenin signalling in TNBC stem cells. |
| first_indexed | 2025-11-14T10:41:12Z |
| format | Thesis |
| id | curtin-20.500.11937-69390 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:41:12Z |
| publishDate | 2018 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-693902018-08-03T02:04:20Z Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling Pohl, Sebastian Öther-Gee Breast cancer is the most common cause of malignancy affecting women worldwide. This thesis focusses on the role of DDX20 in regulating Wnt/β-catenin signalling and its impact on cell fate in triple-negative breast cancer (TNBC). The results of this study demonstrated a new role for DDX20-mediated Wnt signalling governing intracellular redox and mitochondrial function. Furthermore, we have determined that DDX20 is an essential regulator of Wnt/β-catenin signalling in TNBC stem cells. 2018 Thesis http://hdl.handle.net/20.500.11937/69390 Curtin University fulltext |
| spellingShingle | Pohl, Sebastian Öther-Gee Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling |
| title | Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling |
| title_full | Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling |
| title_fullStr | Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling |
| title_full_unstemmed | Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling |
| title_short | Mediation of triple-negative breast cancer cell fate via cellular redox and Wnt signalling |
| title_sort | mediation of triple-negative breast cancer cell fate via cellular redox and wnt signalling |
| url | http://hdl.handle.net/20.500.11937/69390 |