Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans
© 2018 American Chemical Society. Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia relate...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
American Chemical Society
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/68833 |
| _version_ | 1848761900736708608 |
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| author | Drummond, E. Flynn, S. Whelan, H. Nongonierma, A. Holton, T. Robinson, A. Egan, T. Cagney, G. Shields, D. Gibney, E. Newsholme, Philip Gaudel, C. Jacquier, J. Noronha, N. Fitzgerald, R. Brennan, L. |
| author_facet | Drummond, E. Flynn, S. Whelan, H. Nongonierma, A. Holton, T. Robinson, A. Egan, T. Cagney, G. Shields, D. Gibney, E. Newsholme, Philip Gaudel, C. Jacquier, J. Noronha, N. Fitzgerald, R. Brennan, L. |
| author_sort | Drummond, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 American Chemical Society. Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia related parameters in an animal model and in humans. Following screening for the ability to stimulate insulin secretion in pancreatic beta cells, a casein hydrolysate was selected and further studied in the ob/ob mouse model. An acute postprandial study was performed in 62 overweight and obese adults. Acute and long-term supplementation with the casein hydrolysate in in vivo studies in mice revealed a glucose lowering effect and a lipid reducing effect of the hydrolysate (43% reduction in overall liver fat). The postprandial human study revealed a significant increase in insulin secretion (p = 0.04) concomitant with a reduction in glucose (p = 0.03). The area under the curve for the change in glucose decreased from 181.84 ± 14.6 to 153.87 ± 13.02 (p = 0.009). Overall, the data supports further work on the hydrolysate to develop into a functional food product. |
| first_indexed | 2025-11-14T10:39:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-68833 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:39:01Z |
| publishDate | 2018 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-688332018-06-29T12:35:47Z Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans Drummond, E. Flynn, S. Whelan, H. Nongonierma, A. Holton, T. Robinson, A. Egan, T. Cagney, G. Shields, D. Gibney, E. Newsholme, Philip Gaudel, C. Jacquier, J. Noronha, N. Fitzgerald, R. Brennan, L. © 2018 American Chemical Society. Evidence exists to support the role of dairy derived proteins whey and casein in glycemic management. The objective of the present study was to use a cell screening method to identify a suitable casein hydrolysate and to examine its ability to impact glycemia related parameters in an animal model and in humans. Following screening for the ability to stimulate insulin secretion in pancreatic beta cells, a casein hydrolysate was selected and further studied in the ob/ob mouse model. An acute postprandial study was performed in 62 overweight and obese adults. Acute and long-term supplementation with the casein hydrolysate in in vivo studies in mice revealed a glucose lowering effect and a lipid reducing effect of the hydrolysate (43% reduction in overall liver fat). The postprandial human study revealed a significant increase in insulin secretion (p = 0.04) concomitant with a reduction in glucose (p = 0.03). The area under the curve for the change in glucose decreased from 181.84 ± 14.6 to 153.87 ± 13.02 (p = 0.009). Overall, the data supports further work on the hydrolysate to develop into a functional food product. 2018 Journal Article http://hdl.handle.net/20.500.11937/68833 10.1021/acs.jafc.7b05550 American Chemical Society restricted |
| spellingShingle | Drummond, E. Flynn, S. Whelan, H. Nongonierma, A. Holton, T. Robinson, A. Egan, T. Cagney, G. Shields, D. Gibney, E. Newsholme, Philip Gaudel, C. Jacquier, J. Noronha, N. Fitzgerald, R. Brennan, L. Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans |
| title | Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans |
| title_full | Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans |
| title_fullStr | Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans |
| title_full_unstemmed | Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans |
| title_short | Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans |
| title_sort | casein hydrolysate with glycemic control properties: evidence from cells, animal models, and humans |
| url | http://hdl.handle.net/20.500.11937/68833 |