Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions
© The Authors 2016. Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly...
| Main Authors: | , , |
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| Format: | Journal Article |
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CSIRO Publishing
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/68534 |
| _version_ | 1848761825934442496 |
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| author | Duczynski, J. Fuller, Rebecca Stewart, S. |
| author_facet | Duczynski, J. Fuller, Rebecca Stewart, S. |
| author_sort | Duczynski, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © The Authors 2016. Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times. |
| first_indexed | 2025-11-14T10:37:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-68534 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:37:50Z |
| publishDate | 2016 |
| publisher | CSIRO Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-685342018-09-28T08:11:11Z Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions Duczynski, J. Fuller, Rebecca Stewart, S. © The Authors 2016. Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times. 2016 Journal Article http://hdl.handle.net/20.500.11937/68534 10.1071/CH16097 CSIRO Publishing restricted |
| spellingShingle | Duczynski, J. Fuller, Rebecca Stewart, S. Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions |
| title | Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions |
| title_full | Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions |
| title_fullStr | Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions |
| title_full_unstemmed | Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions |
| title_short | Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions |
| title_sort | tert-butyldimethylsilyl amine (tbdms-nh2): a mild and green reagent for the protection of benzyl alcohols, phenols, and carboxylic acids under solvent-free conditions |
| url | http://hdl.handle.net/20.500.11937/68534 |