Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters
© 2017 Elsevier B.V. Ciprofloxacin (CIP) has been widely used to treat many types of bacterial infections. Herein, we reported a green approach for preparation of CIP nanoparticles via solvent anti-solvent precipitation by using subcritical water-ethanol mixture as the solvent. The solubility of CIP...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/68532 |
| _version_ | 1848761825373454336 |
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| author | Pu, Y. Lu, J. Wang, D. Cai, F. Wang, J. Foster, Neil Chen, Jianping |
| author_facet | Pu, Y. Lu, J. Wang, D. Cai, F. Wang, J. Foster, Neil Chen, Jianping |
| author_sort | Pu, Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Elsevier B.V. Ciprofloxacin (CIP) has been widely used to treat many types of bacterial infections. Herein, we reported a green approach for preparation of CIP nanoparticles via solvent anti-solvent precipitation by using subcritical water-ethanol mixture as the solvent. The solubility of CIP in subcritical water-ethanol mixture (with various ethanol ratio of 0, 5, and 20 wt%) at the temperature range from 100 °C to 170 °C and constant pressure of 4 MPa were measured. The chemical structure of CIP was stable after processed in subcritical water-ethanol mixture at up to 170 °C, confirmed by Fourier transformed infrared analysis. The obtained solubility data of CIP were correlated using a modified Apelblat model and the results of the predicted solubility show good agreement with the experimental value. The nanonization of CIP via solvent anti-solvent precipitation process that used the tunable solvent power of subcritical water-ethanol mixture was conducted. Two kinds of no-ionic, hydrophilic polymer, including polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG), were introduced as stabilizers in the precipitation process to obtain CIP nanoparticle with improved dissolution rate. These results show that as-synthesized CIP nanoparticles are promising for oral administration of CIP drugs. |
| first_indexed | 2025-11-14T10:37:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-68532 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:37:49Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-685322018-06-29T12:35:02Z Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters Pu, Y. Lu, J. Wang, D. Cai, F. Wang, J. Foster, Neil Chen, Jianping © 2017 Elsevier B.V. Ciprofloxacin (CIP) has been widely used to treat many types of bacterial infections. Herein, we reported a green approach for preparation of CIP nanoparticles via solvent anti-solvent precipitation by using subcritical water-ethanol mixture as the solvent. The solubility of CIP in subcritical water-ethanol mixture (with various ethanol ratio of 0, 5, and 20 wt%) at the temperature range from 100 °C to 170 °C and constant pressure of 4 MPa were measured. The chemical structure of CIP was stable after processed in subcritical water-ethanol mixture at up to 170 °C, confirmed by Fourier transformed infrared analysis. The obtained solubility data of CIP were correlated using a modified Apelblat model and the results of the predicted solubility show good agreement with the experimental value. The nanonization of CIP via solvent anti-solvent precipitation process that used the tunable solvent power of subcritical water-ethanol mixture was conducted. Two kinds of no-ionic, hydrophilic polymer, including polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG), were introduced as stabilizers in the precipitation process to obtain CIP nanoparticle with improved dissolution rate. These results show that as-synthesized CIP nanoparticles are promising for oral administration of CIP drugs. 2017 Journal Article http://hdl.handle.net/20.500.11937/68532 10.1016/j.powtec.2017.08.038 Elsevier restricted |
| spellingShingle | Pu, Y. Lu, J. Wang, D. Cai, F. Wang, J. Foster, Neil Chen, Jianping Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters |
| title | Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters |
| title_full | Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters |
| title_fullStr | Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters |
| title_full_unstemmed | Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters |
| title_short | Nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: Solubility and precipitation parameters |
| title_sort | nanonization of ciprofloxacin using subcritical water-ethanol mixture as the solvent: solubility and precipitation parameters |
| url | http://hdl.handle.net/20.500.11937/68532 |