Potential role of genipin in cancer therapy
© 2018 Elsevier Ltd Genipin, an aglycone derived from the iridoid glycoside, geniposide, is isolated and characterized from the extract of Gardenia jasminoides Ellis fruit (family Rubiaceae). It has long been used in traditional oriental medicine for the prevention and treatment of several inflammat...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Academic Press
2018
|
| Online Access: | http://hdl.handle.net/20.500.11937/68494 |
| _version_ | 1848761816487821312 |
|---|---|
| author | Shanmugam, M. Shen, H. Tang, F. Arfuso, Frank Rajesh, M. Wang, L. Kumar, Alan Prem Bian, J. Goh, B. Bishayee, A. Sethi, G. |
| author_facet | Shanmugam, M. Shen, H. Tang, F. Arfuso, Frank Rajesh, M. Wang, L. Kumar, Alan Prem Bian, J. Goh, B. Bishayee, A. Sethi, G. |
| author_sort | Shanmugam, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Elsevier Ltd Genipin, an aglycone derived from the iridoid glycoside, geniposide, is isolated and characterized from the extract of Gardenia jasminoides Ellis fruit (family Rubiaceae). It has long been used in traditional oriental medicine for the prevention and treatment of several inflammation driven diseases, including cancer. Genipin has been shown to have hepatoprotective activity acting as a potent antioxidant and inhibitor of mitochondrial uncoupling protein 2 (UCP2), and also reported to exert significant anticancer effects. It is an excellent crosslinking agent that helps to make novel sustained or delayed release nanoparticle formulations. In this review, we present the latest developments of genipin as an anticancer agent and briefly describe its diverse mechanism(s) of action. Several lines of evidence suggest that genipin is a potent inhibitor of UCP2, which functions as a tumor promoter in a variety of cancers, attenuates generation of reactive oxygen species and the expression of matrix metalloproteinase 2, as well as induces caspase-dependent apoptosis in vitro and in in vivo models. These finding suggests that genipin can serve as both a prominent anticancer agent as well as a potent crosslinking drug that may find useful application in several novel pharmaceutical formulations. |
| first_indexed | 2025-11-14T10:37:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-68494 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:37:41Z |
| publishDate | 2018 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-684942018-06-29T12:34:53Z Potential role of genipin in cancer therapy Shanmugam, M. Shen, H. Tang, F. Arfuso, Frank Rajesh, M. Wang, L. Kumar, Alan Prem Bian, J. Goh, B. Bishayee, A. Sethi, G. © 2018 Elsevier Ltd Genipin, an aglycone derived from the iridoid glycoside, geniposide, is isolated and characterized from the extract of Gardenia jasminoides Ellis fruit (family Rubiaceae). It has long been used in traditional oriental medicine for the prevention and treatment of several inflammation driven diseases, including cancer. Genipin has been shown to have hepatoprotective activity acting as a potent antioxidant and inhibitor of mitochondrial uncoupling protein 2 (UCP2), and also reported to exert significant anticancer effects. It is an excellent crosslinking agent that helps to make novel sustained or delayed release nanoparticle formulations. In this review, we present the latest developments of genipin as an anticancer agent and briefly describe its diverse mechanism(s) of action. Several lines of evidence suggest that genipin is a potent inhibitor of UCP2, which functions as a tumor promoter in a variety of cancers, attenuates generation of reactive oxygen species and the expression of matrix metalloproteinase 2, as well as induces caspase-dependent apoptosis in vitro and in in vivo models. These finding suggests that genipin can serve as both a prominent anticancer agent as well as a potent crosslinking drug that may find useful application in several novel pharmaceutical formulations. 2018 Journal Article http://hdl.handle.net/20.500.11937/68494 10.1016/j.phrs.2018.05.007 Academic Press restricted |
| spellingShingle | Shanmugam, M. Shen, H. Tang, F. Arfuso, Frank Rajesh, M. Wang, L. Kumar, Alan Prem Bian, J. Goh, B. Bishayee, A. Sethi, G. Potential role of genipin in cancer therapy |
| title | Potential role of genipin in cancer therapy |
| title_full | Potential role of genipin in cancer therapy |
| title_fullStr | Potential role of genipin in cancer therapy |
| title_full_unstemmed | Potential role of genipin in cancer therapy |
| title_short | Potential role of genipin in cancer therapy |
| title_sort | potential role of genipin in cancer therapy |
| url | http://hdl.handle.net/20.500.11937/68494 |