Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP.
Sensing environmental temperature is a key factor allowing individuals to maintain thermal homeostasis via thermoregulatory mechanisms, including changes to skin blood flow. Among transient receptor potential channels, transient receptor potential vanilloid 3 (TRPV3) is a heat-activated cation chann...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/68460 |
| _version_ | 1848761807599042560 |
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| author | Fromy, B. Josset-Lamaugarny, A. Aimond, G. Pagnon-Minot, A. Marics, I. Tattersall, Glenn Moqrich, A. Sigaudo-Roussel, D. |
| author_facet | Fromy, B. Josset-Lamaugarny, A. Aimond, G. Pagnon-Minot, A. Marics, I. Tattersall, Glenn Moqrich, A. Sigaudo-Roussel, D. |
| author_sort | Fromy, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Sensing environmental temperature is a key factor allowing individuals to maintain thermal homeostasis via thermoregulatory mechanisms, including changes to skin blood flow. Among transient receptor potential channels, transient receptor potential vanilloid 3 (TRPV3) is a heat-activated cation channel highly expressed in keratinocytes. However, the role of TRPV3 in triggering heat-evoked cutaneous vasodilation is unknown. Using a murine in vivo model of local acute environmental heat exposure in the skin, we show that TRPV3 is involved in the local thermoregulatory control of skin blood flow by initiating the release of calcitonin gene-related peptide and nitric oxide in response to local heating of the skin. In addition to their contribution in local heat-evoked vasodilation, TRPV3, calcitonin gene-related peptide, and nitric oxide also contribute to internal body temperature stability during passive whole-body heating. This study provides in vivo demonstration of the role of TRPV3 as a strong modulator of cutaneous vascular thermoregulatory mechanisms. |
| first_indexed | 2025-11-14T10:37:33Z |
| format | Journal Article |
| id | curtin-20.500.11937-68460 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:37:33Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-684602018-06-29T12:35:00Z Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. Fromy, B. Josset-Lamaugarny, A. Aimond, G. Pagnon-Minot, A. Marics, I. Tattersall, Glenn Moqrich, A. Sigaudo-Roussel, D. Sensing environmental temperature is a key factor allowing individuals to maintain thermal homeostasis via thermoregulatory mechanisms, including changes to skin blood flow. Among transient receptor potential channels, transient receptor potential vanilloid 3 (TRPV3) is a heat-activated cation channel highly expressed in keratinocytes. However, the role of TRPV3 in triggering heat-evoked cutaneous vasodilation is unknown. Using a murine in vivo model of local acute environmental heat exposure in the skin, we show that TRPV3 is involved in the local thermoregulatory control of skin blood flow by initiating the release of calcitonin gene-related peptide and nitric oxide in response to local heating of the skin. In addition to their contribution in local heat-evoked vasodilation, TRPV3, calcitonin gene-related peptide, and nitric oxide also contribute to internal body temperature stability during passive whole-body heating. This study provides in vivo demonstration of the role of TRPV3 as a strong modulator of cutaneous vascular thermoregulatory mechanisms. 2018 Journal Article http://hdl.handle.net/20.500.11937/68460 10.1016/j.jid.2017.10.006 Nature Publishing Group restricted |
| spellingShingle | Fromy, B. Josset-Lamaugarny, A. Aimond, G. Pagnon-Minot, A. Marics, I. Tattersall, Glenn Moqrich, A. Sigaudo-Roussel, D. Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. |
| title | Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. |
| title_full | Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. |
| title_fullStr | Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. |
| title_full_unstemmed | Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. |
| title_short | Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. |
| title_sort | disruption of trpv3 impairs heat-evoked vasodilation and thermoregulation: a critical role of cgrp. |
| url | http://hdl.handle.net/20.500.11937/68460 |